Please read the Disclaimer at the end of this page.
EXERCISE-INDUCED ASTHMA OVERVIEW — Exercise-induced asthma occurs when the airways narrow as a result of exercise. The preferred term for this condition is exercise-induced bronchoconstriction (EIB); exercise does not cause asthma, but is frequently an asthma trigger.
A person may have asthma symptoms that become worse with exercise (more common) or may have only exercise-induced bronchoconstriction, without symptoms at other times. If a person's asthma is triggered only during vigorous exercise (exercise-induced bronchoconstriction), they are considered to have mild intermittent asthma. Separate topic reviews discuss asthma in children and adults. (See "Patient education: Asthma treatment in adolescents and adults (Beyond the Basics)" and "Patient education: Asthma symptoms and diagnosis in children (Beyond the Basics)".)
EXERCISE-INDUCED ASTHMA SYMPTOMS — Typical symptoms are shortness of breath, chest tightness, and cough. Exercise-triggered symptoms typically develop 10 to 15 minutes after a brief episode of exercise or about 15 minutes into prolonged exercise. Symptoms typically resolve with rest over 30 to 60 minutes. Exercise-induced symptoms occur more commonly and are more intense when the inhaled air is cold, probably due to changes in the airways that are triggered by the large amounts of relatively cool, dry air inhaled during vigorous activity. (See "Patient education: Trigger avoidance in asthma (Beyond the Basics)".)
EIB is different than simple shortness of breath related to exercise, which generally resolves within five minutes of stopping exercise.
EXERCISE-INDUCED ASTHMA PREVENTION — Exercise is important for your health, even if you have asthma, so it is important to develop a routine that allows exercise. Some patients can often prevent or reduce exercise-induced asthma symptoms by improving their day-to-day asthma control and improving their fitness level with regular exercise.
Nonmedical preventive methods — Breathing cold, dry air during exercise can provoke asthma symptoms. Wearing a loosely fitting scarf or mask when exercising in cold, dry air or exercising where the air is warmer and more humid can help prevent exercise-induced asthma symptoms. Some patients find that warm-up routines before intense exertion can help reduce asthma symptoms.
For people who exercise once a day or less — Preventing exercise-induced bronchoconstriction usually includes use of an inhaled medication prior to exercise.
Rapid-acting bronchodilators — Inhalation of a rapid-acting bronchodilator (eg, two puffs of albuterol) may be taken 5 to 20 minutes before exercise. This inhaler can also be used to relieve symptoms caused by exercise. (See "Patient education: Asthma inhaler techniques in children (Beyond the Basics)" and "Patient education: Inhaler techniques in adults (Beyond the Basics)".)
An alternative is to use a combination inhaler that includes formoterol and an inhaled corticosteroid. Formoterol works as quickly as albuterol and lasts for 12 hours, so it is both a rapid-acting and a long-acting bronchodilator. For prevention of exercise-induced asthma one of the combination inhalers, such as budesonide-formoterol (Symbicort) or mometasone-formoterol (Dulera), can be used one inhalation, at least five minutes prior to exertion. Like albuterol, these medications can also be used to relieve asthma symptoms.
For exertion throughout the day — Some adults and most children exercise intermittently throughout the day, making it hard to use a preventive treatment before each episode of activity. In this case, a long-acting inhaled bronchodilator (eg, salmeterol or formoterol) or a leukotriene modifier (eg, montelukast or zafirlukast) may be recommended to provide day-long protection (see 'Leukotriene modifiers' below).
Long-acting bronchodilators — Long-acting bronchodilators (LABAs), such as salmeterol and formoterol, work for a longer period than rapid-acting bronchodilators. LABAs should always be used in combination with an inhaled glucocorticoid. While formoterol is a LABA, it works as quickly as albuterol. Combination inhalers containing formoterol can be used shortly before exercise (at least five minutes) and can also be used to relieve asthma symptoms that occur despite pretreatment.
Some patients prefer to take their inhaler on a once or twice a day schedule. In this case, inhalers that contain the LABA, salmeterol, and an inhaled corticosteroid (eg, Advair or Seretide in Europe) can be used. These medications are usually taken twice daily and 30 minutes after the morning dose help prevent exercise-induced asthma symptoms for the next 12 hours.
Leukotriene modifiers — Leukotriene modifiers work by decreasing airway narrowing, inflammation, and mucus production. Examples of leukotriene modifiers include montelukast (Singulair) and zafirlukast (Accolate). These are taken in pill form by mouth once daily (montelukast) or twice daily (zafirlukast) and have few side effects. Taken regularly, either of these medications is useful in preventing exercise-induced bronchospasm.
Leukotriene modifiers may be used as an alternative to rapid-acting bronchodilators to prevent exercise-induced bronchoconstriction for patients who prefer or need all-day protection or have difficulty using inhalers.
Montelukast is approved for use as needed before exercise for patients who do not require daily medication. If not taken on a daily basis, montelukast should be taken at least two hours before the start of exercise. If the medication is taken daily, there is no need to take an additional dose prior to exercise.
Leukotriene modifiers are used for prevention of symptoms, NOT for relief of symptoms once they have developed. If asthma symptoms develop despite pretreatment with a leukotriene modifier, a rapid-acting bronchodilator (eg, albuterol, levalbuterol, or budesonide-formoterol) should be used.
ASTHMA ATTACK TREATMENT — The term "asthma attack" is somewhat confusing because it does not distinguish between a mild increase in symptoms and a life-threatening episode. Asthma symptoms may develop during exercise despite pretreatment and may sometimes be more severe than expected. Exercise induced asthma symptoms may be aggravated by changes in air quality, common colds, exposure to allergens, or changes in the weather. These triggers can cause mild, moderate, or severe symptoms to develop. Any of these changes could be considered an asthma "attack."
Some people have periodic, mild attacks that never require emergency care, while others have severe and sudden attacks that require a call for emergency medical services.
Emergency care plan — A patient or parent/caregiver should work with a healthcare provider to formulate an emergency care plan (also called an asthma action plan) that explains specifically what to do if asthma symptoms worsen.
●Mild attacks – Take your rescue medication: most people take two puffs of albuterol or levalbuterol, or one puff of formoterol-budesonide. This may be repeated twenty minutes later, and then periodically (every two to four hours) until symptoms are improved. People who take controller medications, such as inhaled glucocorticoids, may need to increase the dose and should contact their provider for further instruction.
●Severe attack – Take two to six puffs of a rescue medication, depending upon how much the individual can tolerate at once without becoming too jittery. For patients with home nebulizer machines, two treatments can be given, 20 minutes apart.
For severe symptoms or symptoms that worsen or do not improve after initial use of a rescue medication, someone should immediately call for emergency medical assistance. Severe asthma attacks can be fatal if not treated promptly.
In most areas of the United States, emergency medical assistance is available by calling 911. Patients should not attempt to drive to the hospital and should not ask someone else to drive. Calling 911 is safer than driving for two reasons:
●From the moment EMS personnel arrive, they can begin evaluating and treating asthma. When driving in a car, treatment cannot begin until the person arrives in the emergency department.
●If a dangerous complication of asthma occurs on the way to the hospital, EMS personnel may be able to treat the problem immediately.
Following a severe asthma attack, the patient is usually given a three to ten day course of an oral glucocorticoid medication (eg, prednisone, prednisolone). This treatment helps to reduce the risk of a second asthma attack.
Wear medical identification — Many people with medical conditions wear a bracelet, necklace, or similar alert tag at all times. If an accident occurs and the person cannot explain their condition, this will help responders provide appropriate care.
The alert tag should include a list of major medical conditions and allergies, as well as the name and phone number of an emergency contact. One device, Medic Alert (www.medicalert.org), provides a toll-free number that emergency medical workers can call to find out a person's medical history, list of medications, family emergency contact numbers, and healthcare provider names and numbers.
WHERE TO GET MORE INFORMATION — Your healthcare provider is the best source of information for questions and concerns related to your medical problem.
This article will be updated as needed on our web site (www.uptodate.com/patients). Related topics for patients, as well as selected articles written for healthcare professionals, are also available. Some of the most relevant are listed below.
Patient level information — UpToDate offers two types of patient education materials.
The Basics — The Basics patient education pieces answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials.
Patient education: Exercise-induced asthma (The Basics)
Patient education: Asthma in adults (The Basics)
Patient education: Asthma in children (The Basics)
Beyond the Basics — Beyond the Basics patient education pieces are longer, more sophisticated, and more detailed. These articles are best for patients who want in-depth information and are comfortable with some medical jargon.
Patient education: Asthma treatment in adolescents and adults (Beyond the Basics)
Patient education: Asthma symptoms and diagnosis in children (Beyond the Basics)
Patient education: Trigger avoidance in asthma (Beyond the Basics)
Patient education: Asthma inhaler techniques in children (Beyond the Basics)
Patient education: Inhaler techniques in adults (Beyond the Basics)
Professional level information — Professional level articles are designed to keep doctors and other health professionals up-to-date on the latest medical findings. These articles are thorough, long, and complex, and they contain multiple references to the research on which they are based. Professional level articles are best for people who are comfortable with a lot of medical terminology and who want to read the same materials their doctors are reading.
Antileukotriene agents in the management of asthma
An overview of asthma management
Beta agonists in asthma: Acute administration and prophylactic use
Exercise-induced bronchoconstriction
The use of chromones (cromoglycates) in the treatment of asthma
Trigger control to enhance asthma management
Asthma education and self-management
The following organizations also provide reliable health information.
●The National Library of Medicine
(www.nlm.nih.gov/medlineplus/healthtopics.html)
●National Heart, Lung, and Blood Institute
●American Lung Association
●The Asthma and Allergy Foundation of America
●American Academy of Allergy, Asthma, and Immunology
●American College of Allergy, Asthma, and Immunology
(https://acaai.org/asthma/types-of-asthma/exercise-induced-bronchoconstriction-eib/)
[1-6]
