Calculator: Hepatitis discriminant function for estimating disease severity in adults with alcoholic hepatitis

Input

Prothrombin time
Control prothrombin time
Bilirubin

Result

Important: Inputs must be complete to perform calculation.


Index

Notes

Patients with an index ≥32 may benefit from treatment with glucocorticoids.
Please refer to appropriate UpToDate topic reviews for further information.

Equations used

Index = 4.6 * (Prothrombin_time - Control_prothrombin_time) + Bilirubin

References

Ramond MJ, Poynard T, Rueff B, et al. A randomized trial of prednisolone in patients with severe alcoholic hepatitis. N Engl J Med 1992; 326:507.
Friedman SL, McQuaid KR, Grendell JH, et al. Current Diagnosis & Treatment in Gastroenterology, 2nd ed, McGraw-Hill Medical 2002.

Only digits 0 to 9 and a single decimal point (".") are acceptable as numeric inputs. Attempted input of other characters into a numeric field may lead to an incorrect result.

Information on this page may not appear correctly if printed.

All information contained in and produced by the EBMcalc system is provided for educational purposes only. This information should not be used for the diagnosis or treatment of any health problem or disease. THIS INFORMATION IS NOT INTENDED TO REPLACE CLINICAL JUDGMENT OR GUIDE INDIVIDUAL PATIENT CARE IN ANY MANNER. Click here for full notice and disclaimer.

Topic 15641 Version 11.0