| Illness severity | Defining and common clinical findings |
| Asymptomatic | Positive COVID-19 test with no symptoms |
| Minor | Low-grade fever, cough, mild fatigue only, URI symptoms (eg, nasal congestion, sore throat), possibly other symptoms (eg, nausea, vomiting, diarrhea, anosmia, ageusia) |
| Moderate | Persistent fever (38°C [100.4°F] or higher), persistent fatigue (at least 7 days duration), pneumonia (CXR <50% lung parenchyma involvement), chest pain not associated with cough, activity-limiting dyspnea, orthopnea, edema, palpitations, syncope |
| Severe | Dyspnea, hypoxia (SpO2 <94% on room air), need for supplemental oxygen, CXR infiltrates involving >50% lung parenchyma, requiring hospitalization for medical treatment |
| Critical | Respiratory failure (ie, mechanical ventilation, ECLS), shock, multiorgan dysfunction |
