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Reduced-dose glucocorticoid tapering regimen for patients with GPA and MPA

Reduced-dose glucocorticoid tapering regimen for patients with GPA and MPA
Week Patient weight
<50 kg 50 to 75 kg >75 kg
1 50 60 75
2 25 30 40
3 to 4 20 25 30
5 to 6 15 20 25
7 to 8 12.5 15 20
9 to 10 10 12.5 15
11 to 12 7.5 10 12.5
13 to 14 6 7.5 10
15 to 16 5 5 7.5
17 to 18 5 5 7.5
19 to 20 5 5 5
21 to 22 5 5 5
This table provides an example of a reduced-dose, oral glucocorticoid-tapering regimen for a patient with new-onset or relapsing GPA or MPA. Depending on the management by the treating clinicians, it can be initiated immediately or after a course of IV glucocorticoids. After week 22, further reduction in glucocorticoid dose is individualized based on treating provider and patient preference.
GPA: granulomatosis with polyangiitis; MPA: microscopic polyangiitis; IV: intravenous.
From: Walsh M, Merkel PA, Peh CA et al. Plasma exchange and glucocorticoids in severe ANCA-associated vasculitis. N Engl J Med 2020; 382:622. Copyright © 2020 Massachusetts Medical Society. Reprinted with permission from Massachusetts Medical Society.
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