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Drugs that reduce the effect of dopamine in the brain

Drugs that reduce the effect of dopamine in the brain
Type of drug Antidopaminergic mechanism Examples
First-generation antipsychotics D2R antagonism (high potency)
  • Droperidol
  • Flupenthixol
  • Fluphenazine
  • Haloperidol
  • Loxapine
  • Perphenazine
  • Pimozide
  • Thiopropazate
  • Thioproperazine
  • Thiothixene
  • Trifluoperazine
D2R antagonism (low potency)
  • Chlorpromazine
  • Chlorprothixene
  • Levomepromazine
  • Mepazine
  • Mesoridazine
  • Methoxypromazine
  • Pericyazine
  • Pimozide
  • Promazine
  • Thioridazine
Second-generation antipsychotics D2R antagonism
  • Asenapine
  • Clozapine*
  • Iloperidone
  • Lurasidone
  • Olanzapine
  • Paliperidone
  • Quetiapine*
  • Risperidone
  • Sulpiride/L-sulpiride
  • Ziprasidone
Partial D2R agonism
  • Aripiprazole
  • Brexpiprazole
Antiemetic/promotility agents D2R antagonism
  • Clebopride
  • Metoclopramide
  • Prochlorperazine
  • Promethazine*
Calcium channel blockers D2R antagonism
  • Cinnarizine
  • Flunarizine
Dopamine-depleting agents Presynaptic dopamine depletion (no DR activity)
  • Deutetrabenazine
  • Reserpine
  • Tetrabenazine
  • Valbenazine
D2R: dopamine D2 receptor; DR: dopamine receptor.
* Weak antidopaminergic properties.
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