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Common medications with sedating or alerting side effects

Common medications with sedating or alerting side effects
Common medications that have sedating side effects Common medications that have alerting side effects and can disrupt sleep
  • First-generation antihistamines (eg, diphenhydramine)
  • Alerting antidepressants (eg, selective serotonin reuptake inhibitors)
  • Sedating antidepressants (eg, amitriptyline, mirtazapine, trazodone)
  • Glucocorticoids (eg, methylprednisolone, prednisone)
  • Anxiolytics (eg, diazepam, lorazepam)
  • Smoking cessation medications (eg, nicotine patch)
  • Pain medications (eg, opioids)
  • Angiotensin-converting enzyme inhibitors
  • Sedating antiseizure medications (eg, carbamazepine, gabapentin)
  • Diuretics
  • Antipsychotics (eg, olanzapine, quetiapine, risperidone)
  • Nasal decongestants (eg, ephedrine, pseudoephedrine)
  • Hypnotics (eg, benzodiazepines, melatonin agonists, nonbenzodiazepine benzodiazepine receptor agonists)
  • Some immunosuppressants (eg, cyclosporine, tacrolimus)
  • Dopamine agonists (eg, pramipexole, ropinirole)
  • Stimulants (eg, amphetamine, methylphenidate)
  • Some muscle relaxants (eg, cyclobenzaprine)
  • Bronchodilators (eg, aminophylline)
Reproduced from: Cheng P, Drake C. Occupational Sleep Medicine. Sleep Med Clin 2016; 11:65. Table used with the permission of Elsevier Inc. All rights reserved.
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