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Therapeutic monoclonal antibody nomenclature

Therapeutic monoclonal antibody nomenclature
Prefix Target substem
(also called Infix)*
Source substem
(omitted in mAbs named after 2017)
SuffixΔ
Substem Definition Substem Definition
Random and distinctive -ami Serum amyloid protein (SAP)/amyloidosis -a Rat

All products named before 2022:

-mab


Products named from 2022 onward use one of the following:

-tug (unmodified immunoglobulin)

-bart (engineered constant region)

-mig (bispecific or multi-specific)

-ment (variable region fragment)
-ba Bacterial -axo Rat-mouse
-ci Cardiovascular -e Hamster
-eni Enzyme inhibition -i Primate
-fung Fungal -o Mouse
-gro Skeletal muscle mass related growth factors and receptors -u Human
-ki Cytokine and cytokine receptors -xi Chimeric
-ler Allergen -xizu Chimeric-humanized
-ne Neural -zu Humanized
-os Bone    
-pru Immunosuppressive    
-sto Immunostimulatory    
-toxa Toxin    
-ta Tumor    
-vet Veterinary use    
-vi Viral    
Refer to UpToDate and Lexicomp for general information about therapeutic mAbs and specific dosing for individual products.
mAb: monoclonal antibody.
* The final letter could be omitted if it interfered with pronunciation.
¶ Non-human species are no longer used due to high immunogenicity.
Δ Changes to the suffix were made in 2022 to reduce sound-alikes and to specify the immunoglobulin structure.
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