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NCI CTCAE v5.0 cytokine release syndrome

NCI CTCAE v5.0 cytokine release syndrome
Adverse event Grade 1 Grade 2 Grade 3 Grade 4 Grade 5
Cytokine release syndrome Fever with or without constitutional symptoms Hypotension responding to fluids; hypoxia responding to <40% O2 Hypotension managed with one pressor; hypoxia requiring ≥40% O2 Life-threatening consequences; urgent intervention indicated Death
Cytokine release syndrome is a disorder characterized by fever, tachypnea, headache, tachycardia, hypotension, rash, and/or hypoxia; it is caused by the release of cytokines from the cells.
NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; O2: oxygen.
Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).
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