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Bispecific antibody that could be used to replace the function of FVIIIa

Bispecific antibody that could be used to replace the function of FVIIIa
Refer to UpToDate content on treatment of hemophilia for further details.
(A) In normal hemostasis, FVIIIa (orange) forms a complex with FIXa (red) and promotes interaction between FIXa and FX (blue) by binding to both factors on the phospholipid membrane.
(B) A bispecific antibody that can simultaneously bind to FIXa (red) and FX (blue) could mimic the activity of FVIIIa and promote interaction between FIXa and FX on the phospholipid membrane.
FVIIIa: activated coagulation factor VIII (eight); FIXa: activated coagulation factor IX (nine); FX: coagulation factor X (ten).
From: Sampei Z, Igawa T, Soeda et al. Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity. PLoS One 2013; 8:e57479. Available at: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057479 (Accessed on May 10, 2016). Copyright © 2013 Sampei et al. Reproduced under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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