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Differential diagnosis of narcolepsy in children

Differential diagnosis of narcolepsy in children
  Disorder Clinical features Diagnosis
Insufficient nocturnal sleep Inadequate sleep hygiene Inconsistent bedtime and morning wake-up times; abuse of caffeine, alcohol, nicotine, or an illicit substance; use of electronic media around bedtime or at night Detailed history about sleep-wake schedules and habits; sleep logs, actigraphy and urine drug screen
Delayed sleep-wake phase disorder Teenager with inability to fall asleep prior to midnight to 2:00 AM, relatively well-organized and normal sleep quality, inability to awaken fully prior to mid-morning; male predominance Actigraphy and sleep logs show characteristic delayed sleep onset and offset times
Fragmented nocturnal sleep Obstructive sleep apnea Habitual snoring, mouth breathing, daytime sleepiness, obesity, narrow nasal passages or oropharynx PSG: obstructive apneas and hypopneas, oxygen desaturations associated with apneas
Other central disorders of hypersomnolence Idiopathic hypersomnia Chronic hypersomnolence with onset in the teenage years, slightly more common in females, relatively normal nocturnal sleep architecture

PSG: relatively normal sleep architecture, without sleep-disordered breathing or sleep-onset REM periods

MSLT: shortened mean sleep latency (≤8 minutes), but absence of two or more sleep-onset REM periods
Kleine-Levin syndrome Teenager with periods of hypersomnia lasting 10 to 14 days and occurring 2 to 3 times per year; normal sleep-wake function in intervening periods; male predominance; hyperphagia, anorexia, feelings of depersonalization Clinical diagnosis. There are no reliable PSG or MSLT findings, although suppression of N3 sleep and increased sleep fragmentation may be seen in some cases in the early stages
Psychiatric disorders Depression Daytime somnolence and fatigue, apathy, may have anorexia or increased appetite, mood disturbance, suicidal ideation, and disrupted nocturnal sleep Clinical diagnosis
PSG: polysomnography; REM: rapid eye movement; MSLT: multiple sleep latency test.
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