Red blood cell antibodies associated with hemolytic disease of the fetus and newborn

Antigen group	Specific antigen	Disease severity
ABO	A, B	Mild
Chido-Rodgers	Ch1, Ch2, Ch3, Ch4, Ch5, Ch6, WH, Rg1, Rg2	None
Colton	Co^a	Moderate
Colton	Co^b, Co³	Mild
Cromer	Cr^a, Tc^a, Tc^b, Tc^c, Dr^a, Es^a, IFC, WES^a, WES^b, UMC, GUTI, SERF, ZENA, CROV, CRAM	None
Diego	Di^a, Di^b, Wr^a, ELO	Moderate
Diego	Wr^b, Wd^a, Rb^a, WARR, Wu, Bp^a, Mo^a, Hg^a, Vg^a, Sw^a, BOW, NFLD, Jn^a, KREP, Tr^a, Fr^a, SW1	None
Dombrock	Do^a, Do^b, Gy^a, Hy, Jo^a, DOYA	None
Duffy	Fy^a	Moderate
	Fy^b	Mild
	Fy³, Fy⁴, Fy⁵, Fy⁶	None
Forssman	FOR	None
Gerbich	Ge3	Moderate
Gerbich	Ge2, Ge4, Wb, Ls^a, An^a, Dh^a, GEIS	None
Gill	GIL	None
Globoside	PP₁P_k	Severe
H	H	Moderate
I	I, i	None
Indian	In^a, In^b, INFI, INJA	None
Junior	Jr^a	Mild (rare: severe)
John Milton Hagen	JMH, JMHK, JMHL, JMHG, JMHM	None
Kell	K, k, Ku, Js^b	Severe
	Kp^b	Moderate
	Kp^a, Js^a, Ul^a	Mild
	K11, K12, K13, K14, K15, K16, K17, K18, K19, K20, K21, K22, K23, K24, VLAN, TOU, RAZ, KUCI, KANT, KASH, VONG, KALT, KTIM, KYO	None
Kidd	Jk^a, Jk^b	Mild (rare: severe)
Kidd	Jk3	Mild
Knops	Kn^a, Kn^b, McC^a, Sl1, Yka, Sl2, Sl3, KCAM	None
Kx	Kx	None
Langereis	Lan	Mild (rare: moderate)
Landsteiner-Weiner	LW^a, LW^ab, LW^b	None
Lewis	Le^a, Le^b, Le^ab, Le^bH, Ale^b, Ble^b	None
Lutheran	Lu^a	Mild
Lutheran	Lu^b, Lu3, Lu4, Lu5, Lu6, Lu7, Lu8, Lu9, Lu10, Lu11, Lu12, Lu13, Lu14, Lu15, Lu16, Lu17, Au^a, Au^b, Lu20, Lu21	None
Mittenberger	Mi^a	Severe
Mittenberger	Mi^b	None
MNSs	Vw, Mur, MUT	Severe
	U	Moderate (rare: severe)
	S, s, Mt^a, M^v	Moderate
	M	Mild (rare: severe)
	N, Hil, Or	Mild
	He, Mi^a, M^c, M^g, Vr, M^e, St^a, Ri^a, Cl^a, Ny^a, Hut, Far, s^D, Mit, Dantu, Hop, Nob, En^a, En^aKT, 'N', DANE, TSEN, MINY, SAT, ERIK, Os^a, ENEP, ENEH, HAG, ENAV, MARS, ENDA, ENEV, MNTD	None
Ok	Ok^a	None
P1Pk	P, P1, P^k	None
Raph	MER2	None
Rhesus (Rh)	D, c, f, Ce, C^w, cE	Severe
	E, Hr_o	Moderate (rare: severe)
	E^W, hr^s, Tar, Rh32, Hr^B	Moderate
	G	Mild (rare: severe)
	C	Mild (rare: moderate)
	e, C^x, VS, CE, Be^a, JAL	Mild
	V, Hr, C^G, D^W, c-like, hr^H, Rh29, Go^a, Rh33, hr^B, Rh35, Evans, Rh39, Rh41, Rh42, Crawford, Nou, Riv, Sec, CELO, Dav, STEM, FPTT, MAR, BARC, JAHK, DAK, LOCR, CENR, CEST	None
RHAG	Duclos, Ol^a, Duclos-like	None
Scianna	Rd	Mild (rare: moderate)
	SC2	Mild
	SC1, SC3, STAR, SCER, SCAN	None
Vel	Vel	Mild (rare: severe)
Yt (Cartwright)	Yt^a, Yt^b	None
Xg	Xg^a	Mild
Xg	CD99	None
Antigens that do not belong to a blood group system
Cost	Cs^a, Cs^b	None
Er	Er^a, Er^b	None
High-prevalence antigens	At^a	Mild
High-prevalence antigens	AnWj, ABTI, Emm, MAM, PEL, Sd^a	None
Low-prevalence antigens	HJK	Severe
	Kg, Sara	Moderate
	Chr^a, Bi, Bx^a, To^a, Pt^a, Re^a, Je^a, Li^a, Milne, RASM, JFV, JONES, HOFM, REIT	None

Mild disease: published reports of need for bililight therapy or simple transfusion in neonatal life.
Moderate disease: published reports of need for exchange transfusion in neonatal life.
Severe disease: published reports of hydrops fetalis or need for intrauterine transfusions.
Disease severity indicated in parentheses indicates a case report of a more severely affected fetus or neonate has been published, in contrast to the majority of reports.
Refer to UpToDate topics on HDFN for further details.

HDFN: hemolytic disease of the fetus and newborn.

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