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Neurodegenerative diseases and their effect on deglutition

Neurodegenerative diseases and their effect on deglutition
Disease Incidence in general population Prevalence of dysphagia (%) Aspect of deglutition affected Risk of aspiration
Muscular dystrophy 17 to 28:100,000 18 Oral>pharyngeal Low early stages, high late stages
MG 1.7 to 10.4:1,000,000 40 Pharyngeal>oral High (35%)
MS 2 to 7:100,000 24 to 65 Oral/pharyngeal, cortical High
ALS 2:100,000 83 Oral>pharyngeal, cortical High
Parkinson disease 13:100,000 82 Esophageal>oral/pharyngeal, cortical High
MG: myasthenia gravis; MS: multiple sclerosis; ALS: amyotrophic lateral sclerosis.
Reproduced from: Altman KW, Richards A, Goldberg L, et al. Dysphagia in stroke, neurodegenerative disease, and advanced dementia. Otolaryngol Clin N Am 2013; 46:1137. Table used with the permission of Elsevier Inc. All rights reserved.
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