| Role | Medication | Brand name (United States or as noted) | Usual dose |
| Induction of remission | Topical (rectal) mesalamine* | ||
| Suppository | Canasa, Mezera¶, Pentasa¶, Salofalk¶ | 1 gram (one suppository) once daily at bedtime | |
| Retention enema | Pentasa¶, Rowasa, Salofalk¶ | 4 grams once daily at bedtime or twice dailyΔ | |
| Rectal foam (United States: Not available) | Mezera¶ | 2 grams (two actuations) once daily at bedtime | |
| Topical (rectal) glucocorticoids | |||
| Hydrocortisone suppository | Anucort-HC, Anusol-HC, Hemmorex-HC, Proctocort | One suppository (25 or 30 mg) once or twice daily | |
| Hydrocortisone aerosol foam 10% | Cortifoam | 90 mg (one applicatorful) once or twice daily | |
| Hydrocortisone enema | Cortenema, Colocort | 100 mg (one 60 mL unit) once or twice daily | |
| Oral 5-aminosalycylic acid (5-ASA) derivatives | |||
| Sulfasalazine tablet | Azulfidine, Salazopyrin¶ | 4 grams per day in four divided doses | |
| Mesalamine*◊ | |||
| Asacol¶, Asacol HD | 2.4 to 4.8 grams daily in three divided doses | |
| Octasa¶ | 4.8 grams daily or in divided doses | ||
| Salofalk¶ | 3 to 4 grams daily in three to four divided doses | ||
| Delzicol | 2.4 grams daily in three divided doses | |
| Lialda, Mezavant¶ | 2.4 to 4.8 grams daily once daily | |
| Apriso | 1.5 to 4.5 grams once each morning | |
| Pentasa | 4 grams daily in four divided doses | |
| Salofalk sachet¶ | 1.5 to 3 grams daily in one to three divided doses | |
| Pentasa sachet¶ | 2 to 4 grams daily in two to four divided doses | ||
| Olsalazine capsule | Dipentum | 2 to 3 grams daily in two to four divided doses | |
| Balsalazide capsule | Colazal | 6.75 grams daily in three divided doses | |
| Oral glucocorticoids | |||
| Budesonide delayed and extended release tablet, multimatrix (MMX) | Uceris | 9 mg once daily in the morning for eight weeks | |
| Prednisone or prednisolone | 40 to 60 mg once daily in the morning or in two divided doses | ||
| Maintenance of remission | Topical (rectal) mesalamine* | ||
| Suppository | Canasa, Mezera¶, Pentasa¶, Salofalk¶ | 1 gram (one suppository) once daily at bedtime | |
| Enema | Pentasa¶, Rowasa, Salofalk¶ | 1 to 4 grams once daily at bedtimeΔ | |
| Oral 5-aminosalycylic acid (5-ASA) derivatives | |||
| Sulfasalazine tablet | Azulfidine, Salazopyrin¶ | 3 to 4 grams daily in three or four divided doses | |
| Mesalamine*◊ | |||
| Asacol¶, Asacol HD | 1.6 to 2.4 grams daily in one to three divided doses | |
| Delzicol | 1.6 to 2.4 grams daily in one to three divided doses | |
| Lialda, Mezavant¶ | 2.4 to 3.6 grams once daily | |
| Apriso | 1.5 to 3 grams once each morning | |
| Pentasa | 1.5 to 4 grams daily in three to four divided doses | |
| Salofalk sachet¶ | 1.5 to 4 grams daily in one to three divided doses | |
| Pentasa sachet¶ | 2 to 4 grams once daily | ||
| Olsalazine capsule | Dipentum | 1 gram daily in two divided doses | |
| Balsalazide capsule | Colazal | 2.25 to 6.75 grams daily in three divided doses | |
5-ASA: 5-aminosalicylate.
* Mesalamine is United States generic name. Mesalazine is an international generic (nonproprietary) name.
¶ Not available in the United States; however, is available in other areas (eg, Canada, United Kingdom, Europe).
Δ In the United States, mesalamine enema is available as 4 g/60 mL. Other concentrations and dosages are available elsewhere. Refer to product-specific information.
◊ Oral mesalamine may be dosed once daily instead of multiple times daily; there is no significant difference in efficacy and safety.[1,2]