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Selected studies reporting survival for infants 22 to 25 weeks gestation during the initial NICU admission

Selected studies reporting survival for infants 22 to 25 weeks gestation during the initial NICU admission
Study Region/
country		 Study years Survival [n/N (%)] by gestational age (week)
22 23 24 25 Total
Bell*[1] 19 NRN sites, United States 2013 to 2018

Entire cohort:

60/549 (11)

Entire cohort:

535/1083 (49)

Entire cohort:

972/1391 (70)

Entire cohort:

1266/1599 (79)

Entire cohort:

2833/4622 (61)

AT only:

60/200 (30)

AT only:

535/958 (56)

AT only:

972/1362 (71)

AT only:

1266/1584 (80)

AT only:

2833/4104 (69)
Shah*[2] Canada 2010 to 2017 27/85 (32) 339/679 (50) 1040/1504 (69) 1681/2067 (81) 3114/4335 (72)
Humburg*[3] Germany 2011 to 2016 60/105 (57) 355/576 (62) 868/1165 (75) 1012/1217 (90) 2295/3063 (75)
NEPS2[4] Norway 2013 to 2014 3/17 (18) 12/42 (29) 35/62 (56) 59/70 (84) 109/191 (57)
Stoll*[5] 26 NRN sites, United States 2012 7/75 (9) 50/150 (33) 174/269 (65) 249/308 (81) 480/802 (60)
EPIPAGE-2Δ[6] 26 regions in France 2011 0/58 (0) 1/89 (1) 58/186 (31) 182/308 (59) 241/641 (38)
Anderson[7] State of California 2007 to 2011 29/450 (6) 162/602 (27) 458/766 (60) 621/796 (78) 1270/2614 (49)
Rysavy[8] 24 NRN sites, United States 2006 to 2011

Entire cohort:

79/357 (5)

Entire cohort:

181/755 (24)

Entire cohort:

634/1152 (55)

Entire cohort:

919/1277 (72)

Entire cohort:

1813/3541 (51)

AT only:

18/79 (23)

AT only:

179/542 (33)

AT only:

638/1119 (57)

AT only:

905/1257 (72)

AT only:

1740/2997 (58)
Field*[9,10] Trent, United Kingdom 2006 to 2010 0/1 (0) 16/80 (20) 66/151 (44) 137/204 (67) 219/436 (50)
2000 to 2005 0/9 (0) 12/65 (18) 82/198 (41) 142/229 (63) 236/497 (47)
1994 to 1999 0/15 (0) 15/81 (19) 40/165 (24) 119/229 (52) 174/490 (36)
Carlo[11] 23 NRN sites, United States 1993 to 2009

ANS:

32/118 (27)

ANS:

480/1147 (42)

ANS:

1799/2976 (60)

ANS:

2721/3555 (77)

ANS:

5032/7796 (64)

No ANS:

50/283 (18)

No ANS:

225/831 (27)

No ANS:

399/814 (49)

No ANS:

528/804 (66)

No ANS:

1202/2732 (44)
EXPRESS◊[12] Sweden 2004 to 2007 5/51 (10) 53/101 (53) 96/144 (67) 167/205 (81) 321/501 (64)
Stoll*[13] 20 NRN sites, United States 2003 to 2007 25/421 (6) 226/871 (26) 754/1370 (55) 1079/1498 (72) 2084/4160 (50)
EPICure2[14] United Kingdom; Ireland 2006 3/152 (2) 66/339 (19) 178/441 (40) 346/521 (66) 593/1453 (40)
Itabashi*[15] Japan 2005 33/97 (34) 153/282 (54) 324/423 (77) 428/501 (85) 938/1303 (72)
Ishii*[16] 20 NRN sites, Japan 2003 to 2005 28/75 (37) 158/245 (64) 258/332 (78) 347/405 (86) 791/1057 (75)
Tyson§[17] 19 NRN sites, United States 1998 to 2003 (5) (26) (56) (75) 2267/4446 (51)
Epibel*[18] 19 perinatal centers in Belgium 1999 to 2000 0/2 (0) 1/18 (6) 19/65 (29) 50/90 (56) 175/322 (54)
NEPS1*[19] Norway 1999 to 2000 0/2 (0) 9/23 (39) 35/68 (60) 55/69 (80) 99/152 (65)
EpipageΔ[20] 9 regions in France 1997 0/16 (0) 0/30 (0) 13/42 (31) 59/119 (50) 72/207 (35)
EPICure1*[21] United Kingdom; Ireland 1995 2/22 (9) 26/131 (20) 100/298 (34) 186/357 (52) 314/811 (39)

NICU: neonatal intensive care unit; NRN: Neonatal Research Network; ANS: antenatal steroid therapy; AT: active treatment.

* Survival of NICU admissions to discharge.

¶ Survival of live births to 1 year.

Δ Survival of live births including infants who died in the delivery room and were not admitted to the NICU.

◊ Survival of NICU admissions to 1 year.

§ Survival of NICU admissions until 18 to 22 months corrected age.
References:
  1. Bell EF, Hintz SR, Hansen NI, et al. Mortality, In-Hospital Morbidity, Care Practices, and 2-Year Outcomes for Extremely Preterm Infants in the US, 2013-2018. JAMA 2022; 327:248.
  2. Shah PS, Rau S, Yoon EW, et al. Actuarial Survival Based on Gestational Age in Days at Birth for Infants Born at <26 Weeks of Gestation. J Pediatr 2020; 225:97.
  3. Humberg A, Härtel C, Rausch TK et al. Active perinatal care of preterm infants in the German Neonatal Network. Arch Dis Child Fetal Neonatal Ed 2020; 105:190.
  4. Stensvold HJ, Klingenberg C, Stoen R, et al. Neonatal morbidity and 1-year survival of extremely preterm infants. Pediatrics 2017; 139:e20161821.
  5. Stoll BJ, Hansen NI, Bell EF, et al. Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012. JAMA 2015; 314:1039.
  6. Ancel PY, Goffinet F, et al. Survival and morbidity of preterm children born at 22 through 34 weeks' gestation in France in 2011: Results of the EPIPAGE-2 Cohort Study. JAMA Pediatrics 2015; 169:230.
  7. Anderson JG, Baer RJ, Partridge JC, et al. Survival and Major Morbidity of Extremely Preterm Infants: A Population-Based Study. Pediatrics 2016; 138:320154434.
  8. Rysavy MA, Li L, Bell EF, et al. Between-Hospital Variation in Treatment and Outcomes in Extremely Preterm Infants. N Engl J Med 2015; 372:1801.
  9. Field DJ, Dorling JS, Manktelow BN, Draper ES. Survival of extremely premature babies in a geographically defined population: prospective cohort study of 1994-9 compared with 2000-5. BMJ 2008; 336:1221.
  10. Seaton SE, King S, Manktelow BN, et al. Arch Dis Child Fetal Neonatal Ed 2013; 98:F15.
  11. Carlo WA, McDonald SA, Fanaroff AA, et al. Association of antenatal corticosteroids with mortality and neurodevelopmental outcomes among infants born at 22 to 25 weeks' gestation. JAMA 2011; 306:2348.
  12. EXPRESS Group, Fellman V, Hellström-Westas L, et al. One-year survival of extremely preterm infants after active perinatal care in Sweden. JAMA 2009; 301:2225.
  13. Stoll BJ, Hansen NI, Bell EF, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010; 126:443.
  14. Moore T, Hennessy EM, Myles J, et al. Neurological and developmental outcome in extremely preterm children born in England in 1995 and 2006: the EPICure studies. BMJ 2012; 345:e7961.
  15. Itabashi K, Horiuchi T, Kusuda S, et al. Mortality rates for extremely low birth weight infants born in Japan in 2005. Pediatrics 2009; 123:445.
  16. Ishii N, Kono Y, Yonemoto N, et al. Outcomes of infants born at 22 and 23 weeks' gestation. Pediatrics 2013; 132:62.
  17. Tyson JE, Parikh NA, Langer J, et al. Intensive care for extreme prematurity--moving beyond gestational age. N Engl J Med 2008; 358:1672.
  18. Vanhaesebrouck P, Allegaert K, Bottu J, et al. The EPIBEL Study: Outcomes to discharge from hospital for extremely preterm infants in Belgium. Pediatrics 2004; 114:663.
  19. Markestad T, Kaaresen PI, Rønnestad A, et al. Early death, morbidity, and need of treatment among extremely premature infants. Pediatrics 2005; 115:1289.
  20. Larroque B, Bréart G, Kaminski M, et al. Survival of very preterm infants: Epipage, a population based cohort study. Arch Dis Child Fetal Neonatal Ed 2004; 89:F139.
  21. Costeloe K, Hennessy E, Gibson AT, et al. The EPICure study: outcomes to discharge from hospital for infants born at the threshold of viability. Pediatrics 2000; 106:659.
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