Your activity: 130 p.v.
your limit has been reached. plz Donate us to allow your ip full access, Email: sshnevis@outlook.com

Nociceptor sensitization following tissue injury

Nociceptor sensitization following tissue injury
Nociceptor sensitization is partly mediated by the release of toxic substances (potassium, prostaglandin, bradykinins, and substance P) from damaged tissue. Those toxic substances excite nociceptors and increase their sensitivity to pain (hyperalgesia). Substance P, released by an axon reflex, induces vasodilation and mast-cell degranulation leading to histamine and serotonin release. These inflammatory agents sensitize damaged tissue and surrounding nociceptors even further prolonging the hypersensitivity state (secondary hyperalgesia).
K+: potassium; PG: prostaglandin; BK: bradykinin; SP: substance P; 5HT: serotonin.
Redrawn from: Sosnowski M, Lebrun P, Fodderie L. Anesth Clin North Am 1992; 10:211.
Graphic 63962 Version 7.0