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Epidemiology, pathogenesis, and clinical manifestations of celiac disease in adults

Epidemiology, pathogenesis, and clinical manifestations of celiac disease in adults
Authors:
Detlef Schuppan, MD, PhD
Walburga Dieterich, PhD
Section Editor:
J Thomas Lamont, MD
Deputy Editor:
Shilpa Grover, MD, MPH, AGAF
Literature review current through: Dec 2022. | This topic last updated: Jul 20, 2022.

INTRODUCTION — Celiac disease, also known as gluten-sensitive enteropathy, is a common immune-mediated inflammatory disease of the small intestine caused by sensitivity to dietary gluten and related proteins in genetically predisposed individuals. The epidemiology, pathogenesis, and clinical manifestations of celiac disease will be reviewed here. Its management and the use of antibodies for diagnosis are presented separately. (See "Management of celiac disease in adults" and "Diagnosis of celiac disease in adults".)

PATHOGENESIS

Genetic factors — Celiac disease is an immune disorder triggered by an environmental agent (the gluten component of wheat and related cereals) in genetically predisposed individuals [1,2]. The genetic basis of celiac disease is supported by the frequent intrafamilial occurrence and the remarkably close association with the human leukocyte antigen (HLA) DR3-DQ2 and/or DR4-DQ8 gene locus. More than 99 percent of individuals with celiac disease have HLA DR3-DQ2 and/or DR4-DQ8, compared with 30 to 40 percent of the general population of most countries. Homozygosity for HLA DQ2 has been associated with an increased risk for celiac disease and enteropathy-associated T-cell lymphoma (table 1) [3-5]. It has been estimated that the HLA contribution to the development of celiac disease among siblings is 36 percent [6]. Thus, another gene or genes at an HLA-unlinked locus must also participate [7-11]. Celiac disease is associated with a number of autoimmune disorders, including type 1 diabetes mellitus and autoimmune thyroid disease [12,13]. A particular association was found with chromosome 15q26, which contains a type 1 diabetes susceptibility locus [8,9,12], and with chromosome 5q and possibly 11q [9]. (See "Epidemiology, pathogenesis, and clinical manifestations of celiac disease in children", section on 'Genetic factors'.)

Several non-HLA locus genes conferring risk for celiac disease have also been identified and an increasing number of non-HLA risk alleles have been associated with an increased risk of celiac disease [10,11,14]. Non-HLA genes that may influence susceptibility to the disease have been identified, but their influence has not been confirmed. However, these polymorphisms, even when taken together, contribute only 3 to 4 percent to the genetic risk for celiac disease, as compared with 30 to 40 percent for HLA-DQ2 or -DQ8.

Mucosal immune response — In patients with celiac disease, immune responses to gliadin fractions promote an inflammatory reaction, characterized by infiltration of the lamina propria and the epithelium with chronic inflammatory cells and villous atrophy. This response is mediated by both the innate and adaptive immune systems.

●Adaptive immune response  

•Gliadin reactive T cells – The adaptive response is mediated by gliadin (gluten)-reactive T-cells in the lamina propria that recognize gliadin peptides bound to HLA-DQ2 or -DQ8 on antigen-presenting cells.

Tissue transglutaminase, a ubiquitous intracellular enzyme, deamidates gluten peptides, increasing their immunogenicity. Tissue transglutaminase is released by inflammatory and endothelial cells and fibroblasts in response to mechanical irritation or inflammation. Once it has been secreted, it crosslinks glutamine-rich proteins such as the gluten proteins from wheat. However, it can also deamidate glutamine residues in gluten to glutamic acid. Deamidation produces a negative charge in gluten peptides that increases their binding to HLA-DQ2 and -DQ8, which potentiates their capacity to stimulate T-cells [15-17].

A 33 amino acid peptide (A-gliadin, peptide 56-89) that is particularly resistant to gastrointestinal peptidases may be the primary initiator of the inflammatory response to gluten in patients with celiac disease [18]. This peptide can be completely degraded by enterocytes in controls but only partly in celiac patients [19]. Enterocytes from patients with celiac disease show only limited digestion of peptide 31-49 of A-gliadin, a peptide that is not recognized by HLA-DQ2/DQ8. The high stability against proteolysis or the incomplete degradation of these gliadin peptides favors them as important initiators of the inflammatory response and toxic effects [19].

Gluten peptide receptor(s) on intestinal epithelial cells may mediate the transport of gluten peptides to the lamina propria where T-cell activation occurs. A study found that CD71 (the transferrin receptor) was increased in patients with celiac disease and was also expressed at the apical pole of enterocytes, in contrast to its usual location at the basolateral pole of enterocytes [20]. CD71 colocalized with secretory IgA and seemed to be responsible for the apical to basal retro-transport of secretory IgA. Gluten peptides that are bound to secretory IgA (ie, IgA anti-gliadin antibodies) may be protected from degradation by the enterocytes, leading to accumulation in the lamina propria where T-cell stimulation occurs [20]. Gluten may also induce an increase in intestinal permeability in patients with celiac disease by binding to chemokine receptor CXCR3 found on enterocytes [21]. (See "Epidemiology, pathogenesis, and clinical manifestations of celiac disease in children".)

●Autoantibodies and intraepithelial lymphocytes – The relative pathogenic importance of humoral versus the established role of cellular immunity in the pathogenesis of celiac disease is uncertain. In a cell culture system, autoantibodies to tissue transglutaminase blocked intestinal epithelial differentiation [16,22]. Tissue transglutaminase may support the bioactivation of transforming growth factor beta 1, which is required for epithelial differentiation, a process that is impaired in celiac disease. Some inhibitory effect of isolated autoantibodies on tissue transglutaminase activity was also demonstrated in vitro [23]. However, residual enzymatic activity appears to be sufficient for protein crosslinking and (gluten) deamidation reactions [24]. Therefore, the mucosal tissue transglutaminase activity in celiac disease, which cannot be completely blocked by the locally produced autoantibodies, may have a role in the pathogenesis of celiac disease [15,25].

The number of intraepithelial lymphocytes, which mainly bear the otherwise infrequent gamma-delta T-cell receptor, is increased in patients with active, gluten-sensitive sprue compared with normal subjects, while patients with refractory sprue also have aberrant lymphocytes with restricted gene rearrangements. The intraepithelial T lymphocytes show increased expression of interferon gamma and IL-10 [26]. However, the pathogenetic role of these lymphocytes, compared with the lamina propria lymphocytes, is controversial [27], and several inflammatory conditions, such as enteric infections and drug and food allergies that are unrelated to celiac disease, can cause intraepithelial lymphocytosis [28,29].

●Innate immune response – Innate responses to wheat proteins (in addition to gluten-mediated activation of pathogenic T-cells) are also involved in the immune response, and perhaps even necessary to trigger the gliadin-specific (adaptive) T-cell response in genetically predisposed individuals [30].

In celiac disease, gluten peptides have been implicated as triggers of innate immune responses not only in intestinal epithelial cells but also in mononuclear cells [30-36]. However, this was not confirmed in a study that identified a family of non-gluten proteins, the wheat amylase-trypsin inhibitors (ATIs), as activators of innate immunity in macrophages, monocytes, and dendritic cells via toll-like receptor 4, the receptor for bacterial lipopolysaccharide [37]. Notably, the ATIs regulate storage proteins and carbohydrates of the grain kernel and serve as pest-resistance proteins of gluten-containing cereals [38-41]. ATIs are highly resistant to intestinal digestion and induce low-level intestinal inflammation as well as intestinal dysbiosis after oral ingestion. They are possibly the major cause of non-celiac "gluten sensitivity" (more correctly "non-celiac wheat" sensitivity), which is defined as dose-dependent intolerance to gluten-containing cereals, with intestinal and extraintestinal manifestations, after exclusion of celiac disease or classical wheat allergy [42,43]. (See "Diagnosis of celiac disease in adults", section on 'Differential diagnosis'.)

EPIDEMIOLOGY

Prevalence — Celiac disease is not limited to individuals ethnically derived from European populations and has increasingly been found in populations of Northern Africa, the Middle East, India, and Northern China [44]. The estimated global prevalence of celiac disease based on serologic studies is approximately 1 percent [45,46]. Epidemiologic studies using serologic tests with biopsy verification have reported prevalences of 1:70 to 1:300 in most countries [47]. Even higher worldwide prevalences were reported by a systemic review and meta-analysis, with a prevalence of 1.4 percent based on serologic results and 0.7 percent found by biopsy results [48]. Overall, the global distribution of the disease seems to parallel the distribution of human leukocyte antigen (HLA) genotypes that predispose to celiac disease, provided that the population is also exposed to gluten [49].

Population-based studies have suggested that recognized cases of celiac disease may only represent the tip of the celiac iceberg. As an example, a study from Italy reported that asymptomatic cases outnumbered symptomatic cases by a ratio of 7:1 [50]. Screening programs based upon antibody testing have demonstrated a high prevalence of celiac disease [44,50-56]. In European and United States cohorts, prevalence estimates range from 1:96 to 1:252 [44,50,52-58]. A large serologic screening study in the United States suggested a prevalence of 1:133 among patients with no risk factors or symptoms [55]. Analysis of self-reported data from the National Health and Nutrition Examination Surveys suggest that prevalence of individuals with celiac disease in the United States has remained stable between 2009 and 2014 [59]. In contrast, a study with Italian school-age children showed a significantly increased prevalence ranging from 0.88 percent when assessed between 1993 and 1995 up to 1.58 percent when assessed between 2015 and 2016 [60].

High risk groups — First- and second-degree relatives of patients with celiac disease are at increased risk [55,61]. In a meta-analysis, the pooled prevalence of celiac disease was 8.9 percent (1:11) for siblings, 7.9 percent (1:13) for offspring, and 3 percent (1:33) for parents of the celiac patient [61].

Other individuals at increased risk for celiac disease include (among several other autoimmune diseases):

●Type 1 diabetes

●Autoimmune thyroiditis

●Down and Turner syndromes

●Pulmonary hemosiderosis (moderate risk)

TERMINOLOGY

Symptomatic disease

Classic celiac disease — The classic celiac disease or gluten-sensitive enteropathy is characterized by diarrhea or signs and symptoms of malabsorption (eg, steatorrhea, weight loss, or other signs of nutrient or vitamin deficiency) or both; villous atrophy; and resolution of the mucosal lesions and symptoms upon withdrawal of gluten-containing foods, usually within a few weeks to months [62]. Patients with classic disease possess antibodies against tissue transglutaminase. (See "Diagnosis of celiac disease in adults", section on 'Serologic evaluation'.)

Atypical celiac disease — Patients with atypical celiac disease lack classic symptoms of malabsorption but may exhibit minor gastrointestinal complaints. They usually have extraintestinal manifestations of celiac disease including anemia, dental enamel defects, osteoporosis, arthritis, increased aminotransferases, neurological symptoms, infertility, and several associated autoimmune diseases. These patients usually have villous atrophy in duodenal biopsies and display positive celiac antibodies, prominently against tissue transglutaminase. (See "Diagnosis of celiac disease in adults", section on 'Serologic evaluation'.)

Subclinical or asymptomatic disease — Patients are asymptomatic and are identified incidentally during endoscopy performed for other indications (picture 1) or by serologic screening of high-risk groups for antibodies against tissue transglutaminase. The term "silent" may be a misnomer; after treatment with a gluten-free diet, many of these patients retrospectively recognize subclinical symptoms that they had not previously considered to be abnormal. Although these patients usually display the characteristic architectural remodeling of the intestinal mucosa, mainly villous atrophy, seen in classic celiac disease, they do not show classic clinical symptoms.

Establishing the diagnosis of subclinical or asymptomatic celiac disease is of potential importance due to the risk of malignancy, the presence of unsuspected nutritional deficiencies, and the association with low-birth weight infants in affected mothers. (See "Management of celiac disease in adults".)

Potential celiac disease — The term is used for patients with positive celiac-specific serum antibodies but normal duodenal mucosal biopsy. Potential celiac disease is also used for patients with positive serology and increased intraepithelial lymphocytes (Marsh 1 lesion) (figure 1). These patients have no symptoms or laboratory signs of malabsorption. However, patients are at risk of developing classic celiac disease, and must be made aware of this possibility and should be monitored.

Latent celiac disease — Latent celiac disease was a previously used term for patients that presented with celiac disease in the past, usually diagnosed in childhood, but who recovered completely with a gluten-free diet and remained "silent" even once a normal diet was resumed [63]. Approximately 20 percent of such patients continued to be in remission (asymptomatic with normal villous architecture) into adulthood and were therefore classified as latent, while the others redeveloped variable degrees of villous atrophy [64]. Latency may be transient and thus regular follow-up of such patients is warranted. Moreover, diagnostic errors such as incorrect orientation and reading of duodenal biopsies may have obscured an otherwise positive histologic finding [65].

Refractory disease — Refractory disease is defined by the persistence of symptoms and villous atrophy despite adherence to a gluten-free diet. Failure to improve on a gluten-free diet is mostly due to poor dietary compliance or other underlying malabsorptive disorders. However, in rare cases, diet-refractory celiac disease may be related to one of the following:

●Non-malignant inflammation of the small intestine, possibly due to a high sensitivity towards minimal amounts of gluten (refractory celiac disease type 1 [RCD1]).

●Semi-malignant inflammatory condition (RCD2).

●Overt enteropathy-associated T-cell lymphoma (EATL).

●Collagenous sprue, a very rare, little understood disorder, which is characterized by subepithelial collagen deposition [66].

●Alternative diagnosis including autoimmune enteropathy, common variable immunodeficiency (CVID; IgG deficiency) or drug-induced villous atrophy.

Patients with refractory celiac disease type 2 or EATL have aberrant intraepithelial lymphocytes with restricted gene rearrangements; the relation of this finding to the resistance to gluten restriction is not known [27].

CLINICAL MANIFESTATIONS — Although classically a disease of infants, celiac disease now often presents later, between the ages of 10 and 40 years. Thus, the impressive clinical picture of a child with life-threatening malabsorption is often replaced by the mostly atypical presentation of adult celiac disease. This is in part due to longer periods of breast-feeding and the later introduction of gluten in the infant diet.

Thus, celiac disease represents a continuum with variable degrees of severity. The severity of symptoms appears to correlate with both histologic severity and tissue transglutaminase titers [67,68].

Gastrointestinal manifestations — Patients may present with classic signs, including diarrhea with bulky, foul-smelling, floating stools due to steatorrhea and flatulence. These symptoms are paralleled by the consequences of malabsorption, such as weight loss, severe anemia, neurologic disorders from deficiencies of B vitamins, and osteopenia from deficiency of vitamin D and calcium.

Adult patients with undiagnosed celiac disease rarely present with profuse diarrhea and severe metabolic disturbances (celiac crisis) [69].

The severity of histologic changes in the small bowel does not necessarily correlate with the severity of clinical manifestations [70]. Although there is a gradient of decreasing severity from the proximal to the distal small intestine, correlating with the higher proximal concentration of dietary gluten, sampling error can occur due to spotty features of mucosal inflammation, or individual differences in gluten digestion and, therefore, a more proximal or distal maximal mucosal exposure to immunogenic gluten peptides. The histologic severity ranges from a mild alteration characterized by increased intraepithelial lymphocytes (type 1 lesion) to a flat mucosa with total mucosal atrophy, complete loss of villi, enhanced epithelial apoptosis, and crypt hyperplasia (type 3 lesion) (picture 2 and figure 1) [62,63,71-74]. (See "Diagnosis of celiac disease in adults", section on 'Endoscopy with small bowel biopsy'.)

Extraintestinal manifestations — A number of nongastrointestinal manifestations of celiac disease have been described. (See "Diagnosis of celiac disease in adults".)

Mucocutaneous

●Dermatitis herpetiformis – Dermatitis herpetiformis is common among patients with celiac disease. The classic clinical finding in dermatitis herpetiformis is the development of multiple intensely pruritic papules and vesicles that occur in grouped ("herpetiform") arrangements. The elbows, dorsal forearms, knees, scalp, back, and buttocks are among the most common sites for lesion development (picture 3A-F). The clinical manifestations, diagnosis, and management of dermatitis herpetiformis are discussed in detail separately. (See "Dermatitis herpetiformis", section on 'Treatment'.)

●Atrophic glossitis – Oral lesions (erythema or atrophy) and a soreness or burning sensation of the tongue have been described in association with celiac disease and respond to a gluten-free diet [75]. Oral symptoms are frequent in patients with classical celiac disease, thus the involvement of the oral cavity is a helpful tool in diagnosis of celiac disease [76].

Metabolic bone disorders — Metabolic bone disease is common in celiac disease and can occur in patients without gastrointestinal symptoms [77-80]. Patients with celiac disease may have bone loss due to secondary hyperparathyroidism from vitamin D deficiency [81]. Osteomalacia due to vitamin D deficiency is also sometimes seen, although its prevalence is unknown [82]. In adults, loss of bone density in the peripheral skeleton may persist despite apparent normalization at axial skeletal sites after patients are on a gluten-free diet [81,83].

The risk of fractures is slightly increased in patients with celiac disease [84]. In a population-based cohort study in which 4732 patients with celiac disease were compared with 23,620 age- and sex-matched controls, the overall hazard ratio for any fracture was 1.3 (95% CI 1.16-1.46). The absolute difference in the overall fracture rate was 3.2 per 1000 person-years.

A higher prevalence of osteoarthritis has also been described in celiac disease, but whether there is a causal relationship is unclear [85].

Hematologic

●Iron deficiency anemia – Celiac disease may be a surprisingly frequent cause of iron deficiency anemia [86-88]. One study of 93 patients presenting for evaluation of iron deficiency anemia found 11 (12 percent) with small bowel biopsy findings compatible with celiac disease [89]. Some had other mucosal abnormalities, such as esophagitis and gastritis, which could have been taken as the cause of the anemia and delayed the discovery of celiac disease. Similar findings were noted in another report in which 6 percent of 85 patients with iron deficiency anemia had celiac disease [86]. The incidence was 20 percent in the subgroup of nonresponders to supplemental iron.

●Hyposplenism – Several case reports have described hyposplenism in association with celiac disease [90-93], the pathogenesis of which is unknown. (See "Management of celiac disease in adults", section on 'Pneumococcal vaccination'.)

Neuropsychiatric — Several reports have described an association between celiac disease and neurologic or psychiatric symptoms including headache, peripheral neuropathy, ataxia, epilepsy, depression, dysthymia, and anxiety [94-109]. However, these studies are limited by a small sample size, retrospective acquisition of data, tertiary referral bias, and potential misclassification of celiac disease, as the diagnosis in some studies was based on the presence of gliadin antibodies rather than duodenal histology or more specific autoantibodies. The association of celiac disease with depression and epilepsy is still unclear as studies have been conflicting [110,111].

Peripheral neuropathies, characterized by burning, tingling, and numbness in hands and feet, have been described in up to 50 percent of patients with celiac disease and may precede its diagnosis [95]. In a large population-based study from Sweden that included 14,000 celiac patients and 70,000 controls, celiac disease was associated with an increased risk of polyneuropathy (hazard ratio 3.4), but not with other neurologic outcomes [112].

In patients with celiac disease, neuropathies may also be associated with lymphoma and deficiencies of vitamins B1 (thiamine), B2 (riboflavin), B3 (niacin), B6 (pyridoxine), B12 (cobalamine), and E. However, vitamin deficiency syndromes are uncommon in the absence of severe and extensive small bowel involvement.

While a gluten-free diet has been shown to have a favorable effect on headache and dysthymia, it has not been demonstrated to improve peripheral neuropathies [94,113]. (See "Overview of water-soluble vitamins" and "Clinical manifestations and diagnosis of vitamin B12 and folate deficiency" and "Overview of vitamin E".)

ASSOCIATED CONDITIONS

Selective IgA deficiency — Selective IgA deficiency has been associated with celiac disease and has been detected in up to 8 percent of patients with celiac disease in some studies [114,115]. Screening for celiac disease in patients with IgA deficiency is discussed in detail separately. (See "Diagnosis of celiac disease in adults".)

Autoimmune disease

●Diabetes mellitus – Celiac disease is closely associated with type 1 diabetes mellitus and polyglandular autoimmune syndrome type III characterized by autoimmune thyroiditis combined with immune-mediated diabetes [116-119]. In several reports, between 2.6 and 7.8 percent of adults with type 1 diabetes had IgA autoantibodies to endomysium or to tissue transglutaminase; most such patients were proven to have celiac disease with small bowel biopsy [120,121]. Many such patients had no overt clinical manifestations of celiac disease [120]. Other reports have demonstrated that as many as 3.5 percent of children of parents with type 1 diabetes have celiac disease, the prevalence of which increases with age [122].

Type 1 diabetes and celiac disease share multiple genetic loci such as HLA-DR3, HLA-DQ2 (HLA-DQ8), and several genetic variations [8,123,124]. This suggests that type 1 diabetes and celiac disease have common features in their pathogenesis, such as tissue damage from autoimmunity or intolerance to dietary antigens. Approximately one-third of patients with type 1 diabetes who have the celiac disease-predisposing haplotype HLA-DQ2 (which is found in 20 to 25 percent of the general Western population) have raised IgA autoantibodies to tissue transglutaminase and are therefore likely to have celiac disease [125]. This is in comparison to a prevalence of tissue transglutaminase autoantibodies in only 2 percent of those without HLA-DQ2.

The age of onset and the severity of diabetes do not appear to be influenced by the presence of celiac disease [120]. Furthermore, celiac disease does not appear to trigger autoimmunity leading to diabetes as suggested in one report [126], since celiac autoantibodies usually develop after the onset of diabetes [127].

Whether a gluten-free diet improves diabetes in patients with both diabetes and celiac disease is unclear. Only two small studies, one retrospective [128] and one short-term [117], investigated the effect of a strict gluten-free diet in patients with type 1 diabetes and silent celiac disease. Patients showed at best a trend toward an increased body mass index, but no change in folate or hemoglobin levels or insulin requirements. However, animal studies suggest that the interplay between gluten exposure and the intestinal immune system can modulate the development of type 1 diabetes. Substitutions of hydrolyzed casein instead of gluten in the diet delayed the onset of type 1 diabetes in BB rats, which spontaneously develop diabetes [129], and a gluten-free diet reduced the incidence of type 1 diabetes in non-obese diabetic mice from 64 to 15 percent [130]. Furthermore, the very early supplementation of newborns' diet with gluten (<3 months) showed an increased risk for islet autoantibodies, which precede type 1 diabetes mellitus [131]. Thus, larger and prospective clinical studies are required to clarify the relationship between celiac disease, type 1 diabetes, and other secondary autoimmunities.

●Thyroid disease – There is an increased incidence of autoimmune thyroid disease among patients with celiac disease [132,133]. Hypothyroidism is more frequent than hyperthyroidism.

●Atopic dermatitis – Patients with celiac disease (and their families) may also be more likely to have atopic dermatitis compared with the general population, although the prevalence of other allergies is not increased [134].

Gastrointestinal disease

Gastroesophageal reflux disease — An association of celiac disease with gastroesophageal reflux disease (GERD) has been reported. In a study of 133 patients with celiac disease and 70 healthy controls, patients with celiac disease had significantly higher GERD symptom scores when compared with controls [135]. Prior to treatment, 30 percent of patients with celiac disease reported moderate to severe symptoms compared with 6 percent of controls. Fifteen percent of patients with atypical or silent cases of celiac disease reported moderate to severe GERD. Three months after initiating a gluten-free diet, GERD symptom scores in patients with celiac disease were comparable to those in the healthy controls.

Eosinophilic esophagitis — The incidence of eosinophilic esophagitis is increased in both children and adults with celiac disease (age-adjusted and sex-adjusted standardized incidence ratio [SIR] 16.0, 95% CI 8.7-25.5) [136-140].

Inflammatory bowel disease — Several case series have demonstrated an association between celiac disease and inflammatory bowel disease (IBD), more frequently with ulcerative colitis than Crohn disease [141,142]. In one case-control study, the risk of IBD in patients with celiac disease was elevated 10-fold, while the risk of celiac disease in patients with IBD was comparable to controls [143]. Of note, two independent studies have found a common proinflammatory polymorphism of the IL-23 receptor gene in both ulcerative colitis and celiac disease [144,145]. First-degree relatives of patients with celiac disease may also be at a fivefold increased risk of developing ulcerative colitis as compared with the general population [146]. In one case-control study that included 51 patients with coexisting IBD and celiac disease and 102 IBD controls, patients with ulcerative colitis and coexisting celiac disease were more likely to have pancolitis as compared with patients with ulcerative colitis alone (odds ratio [OR] 3.3, 95% CI 1.05-21.5) [147]. However, among patients with Crohn disease, there were no phenotypic differences based on the presence of coexisting celiac disease.

Microscopic colitis — Patients with celiac disease have an increased risk of microscopic colitis. In a large cohort study of 1009 patients with celiac disease, 44 (4.3 percent) were diagnosed with microscopic colitis, corresponding to a 72-fold increased risk of microscopic colitis in patients with celiac disease, as compared with the general population [148]. (See "Microscopic (lymphocytic and collagenous) colitis: Clinical manifestations, diagnosis, and management", section on 'Associated conditions'.)

Liver disease

●Elevated aminotransferase – Celiac disease may be associated with nonspecific mild to moderate chronic elevation in serum aminotransferase levels in 15 to 55 percent of patients (alanine aminotransferase is usually slightly greater than aspartate aminotransferase [149,150]). A meta-analysis found that in patients with cryptogenic elevations in aminotransferases, celiac serologies were positive in 6 percent and duodenal biopsies suggested celiac disease in 4 percent [151]. In addition, abnormal serum transaminases were detected in 27 percent of patients with newly diagnosed celiac disease. Serum transaminases normalized in 63 to 90 percent of patients within a year of initiating a gluten-free diet.

●Cholestatic and autoimmune liver disease – Celiac disease has been associated with primary biliary cirrhosis (PBC) [152]. Two large studies suggested a prevalence of 6 to 11 percent in patients with PBC, although these may be overestimates [153,154]. (See "Evaluation and treatment of low bone mass in primary biliary cholangitis (primary biliary cirrhosis)".)

Celiac disease has also been associated with other causes of liver disease [152,155,156]. One study evaluated the risk of liver disease in 13,818 patients with celiac disease from 1964 to 2003, with 66,584 age- and sex-matched controls [156]. Celiac disease was associated with an increased risk of acute hepatitis, chronic hepatitis, and primary sclerosing cholangitis. Adjustment for socioeconomic index or diabetes mellitus had no notable effect on the risk estimates. In addition, prior liver disease was associated with a statistically significant four- to six-fold increased risk of later celiac disease.

Pancreatitis — Large database studies have described an increased risk of pancreatitis (both acute and chronic) in patients with celiac disease [157,158]. Further studies are needed to clarify the strength of the association and potential mechanisms that underlie it.

Menstrual and reproductive issues — On a population basis, women with celiac disease, most of them on a gluten-free diet, have similar overall fertility to the general female population [159,160]. However, women with untreated celiac disease may have later age of menarche, earlier menopause, secondary amenorrhea, recurrent miscarriage, spontaneous abortion, preterm delivery, and low birth weight [160-170].

Male infertility, characterized by abnormalities in sperm motility and morphology as well as a biochemical picture of androgen resistance (high serum testosterone and high luteinizing hormone [LH] concentrations), has been reported in celiac disease [171,172]. In one study of 41 men with celiac disease and high testosterone and LH concentrations, dietary modification led to normalization of the biochemical abnormalities [172]. (See "Causes of male infertility".)

Idiopathic pulmonary hemosiderosis — Coexistence of celiac disease and idiopathic pulmonary hemosiderosis, also known as Lane-Hamilton syndrome, has been reported in a number of cases, and introduction of a gluten-free diet has been associated with remission of pulmonary symptoms in several patients. (See "Idiopathic pulmonary hemosiderosis".)

Cardiovascular disease — Celiac disease, which is often clinically unsuspected, accounts for as many as 5 percent of patients with autoimmune myocarditis or idiopathic dilated cardiomyopathy [173,174]. In one study of nine such patients, none had classic gastrointestinal symptoms of celiac disease (recurrent abdominal pain, diarrhea, and weight loss), but all had iron deficiency anemia refractory to oral iron replacement [173]. Cardiac function improved following a gluten-free diet with or without immunosuppressive therapy. Patients with celiac disease may also be at increased risk for ischemic heart disease [175-179]. (See "Myocarditis: Causes and pathogenesis", section on 'Celiac disease'.)

Kidney disease — Glomerular IgA deposition is common, occurring in as many as one-third of patients. The great majority of affected patients have no clinical manifestations of kidney disease, perhaps because there is no associated activation of complement. (See "IgA nephropathy: Pathogenesis and etiology".)

PROGNOSIS

Cancer risk — Patients with celiac disease are at increased risk for lymphoma and gastrointestinal cancer. Whether the degree of compliance with a gluten-free diet influences the rates of cancers is uncertain [180,181]. The increase in cancer risk in patients with celiac disease is illustrated in the following studies:

●One of the largest population-based studies to address cancer risk in patients with celiac disease included 12,000 patients with celiac disease or dermatitis herpetiformis [182]. Cancer was diagnosed in 249 patients during follow-up (standardized incidence ratio [SIR] 1.3, 95% CI 1.2-1.5), suggesting that the overall increase in cancer risk was modest. The risk of cancer was not increased in children or adolescents. The most common malignancy was lymphoma (SIR 5.9), which accounted for 18 percent of all cancers (image 1). The risk of other digestive tract cancers was also increased, including oropharyngeal (mostly esophageal squamous cell), small intestinal adenocarcinoma, colorectal, and hepatocellular. In contrast, there was a significantly reduced risk of breast cancer. The risk declined with increasing length of follow-up. (See "Clinical presentation and diagnosis of primary gastrointestinal lymphomas".)

●In another large cohort study that evaluated the risk of gastrointestinal (GI) cancers in 28,882 patients with celiac disease (villous atrophy, Marsh score = 3), 12,860 with mild inflammation (Marsh score 1 to 2), and 3705 individuals with potential celiac disease (normal mucosa but positive serology), the risk of incident GI cancers was increased in all three groups in the first year of diagnosis (hazard ratio [HR] 5.95, 9.13, 8.10, respectively) [183]. Although the high incident cancer risk in the first year of diagnosis may be due to ascertainment bias, after the first year of diagnosis, the site-specific risk for small intestinal cancer and hepatocellular carcinoma was increased in patients with celiac disease (HR 2.22 and 1.78) and inflammation (HR 2.49 and 2.17). There was an increased risk of lymphoproliferative malignancy in patients with villous atrophy (HR 2.82) compared with patients with intestinal inflammation without villous atrophy (HR 1.81), but not in individuals with normal mucosa but positive serology celiac disease (HR 0.97) [184]. This risk of lymphoma but not solid tumors remained increased for five years or more after diagnosis despite adherence to a gluten-free diet.

●In a retrospective study that included 48,119 individuals with celiac disease and 239,249 controls, the risk of small bowel adenomas and adenocarcinoma was increased in individuals with celiac disease (HR 5.73 [95% CI, 3.70–8.88] and 3.05 [95% CI, 1.86–4.99], respectively), however, the absolute risk of small bowel adenocarcinoma was low (5 per 10,000 celiac patients over 10 years) [185]. Individuals with celiac disease with mucosal healing had lower rates of small bowel adenocarcinoma, as compared to those with persistent villous atrophy, but the differences were not statistically significant (0.01 versus 0.18 percent, HR 0.18 [95% CI 0.02-1.61]). The risk of carcinoids was not increased in individuals with celiac disease.

Mortality — A number of observational studies have noted a small absolute increase in overall mortality in patients with celiac disease compared with the general population [123,175,180,182,186-192]. The magnitude of mortality risk and its relation to small bowel histopathology was evaluated in a retrospective cohort study that included approximately 29,000 individuals with celiac disease (Marsh stage 3: villous atrophy), 13,000 individuals with only inflammation on biopsy (Marsh stage 1 to 2), and 3700 individuals with normal mucosal histology (Marsh 0), but positive celiac disease serology [175]. There was a significant absolute increase in mortality in all three groups (2.9, 10.8, and 1.7 per 1000 person-years, respectively). The higher absolute mortality among patients with inflammation is partly explained by their older age at study entry. The increase in mortality was largely due to cardiovascular disease and malignancy.

SOCIETY GUIDELINE LINKS — Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately. (See "Society guideline links: Celiac disease" and "Society guideline links: Dermatitis herpetiformis".)

INFORMATION FOR PATIENTS — UpToDate offers two types of patient education materials, "The Basics" and "Beyond the Basics." The Basics patient education pieces are written in plain language, at the 5th to 6th grade reading level, and they answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials. Beyond the Basics patient education pieces are longer, more sophisticated, and more detailed. These articles are written at the 10th to 12th grade reading level and are best for patients who want in-depth information and are comfortable with some medical jargon.

Here are the patient education articles that are relevant to this topic. We encourage you to print or e-mail these topics to your patients. (You can also locate patient education articles on a variety of subjects by searching on "patient info" and the keyword(s) of interest.)

●Basics topics (see "Patient education: Celiac disease (The Basics)")

●Beyond the Basics topics (see "Patient education: Celiac disease in adults (Beyond the Basics)")

PATIENT PERSPECTIVE TOPIC — Patient perspectives are provided for selected disorders to help clinicians better understand the patient experience and patient concerns. These narratives may offer insights into patient values and preferences not included in other UpToDate topics. (See "Patient perspective: Celiac disease".)

SUMMARY AND RECOMMENDATIONS

●Epidemiology – Celiac disease is not limited to individuals ethnically derived from European populations and has increasingly been found in populations of Northern Africa, the Middle East, India, and Northern China. The estimated global prevalence of celiac disease based on serologic studies is approximately 1 percent, and locally can be well above 1 percent. (See 'Prevalence' above.)

●High-risk groups – First- and second-degree relatives of patients with celiac disease are at increased risk for celiac disease. Other high-risk groups include patients with one of the following (see 'High risk groups' above):

•Type 1 diabetes

•Autoimmune thyroiditis

•Several other autoimmune diseases

•Down and Turner syndromes

●Pathogenesis – Celiac disease is an immune disorder triggered by an environmental agent (the gluten component of wheat or related cereals) in genetically predisposed individuals. The genetic basis of celiac disease is supported by the frequent intrafamilial occurrence and the remarkably close association with the human leukocyte antigen (HLA) DR3-DQ2 and/or DR4-DQ8 gene locus. (See 'Pathogenesis' above.)

●Clinical manifestations – Patients with celiac disease may present with classic symptoms related to malabsorption, including diarrhea, steatorrhea, weight loss, and nutrient or vitamin deficiencies. However, the majority of patients with celiac disease exhibit only minor gastrointestinal complaints, have extraintestinal manifestations, or are asymptomatic. (See 'Gastrointestinal manifestations' above and 'Clinical manifestations' above and 'Symptomatic disease' above.)

●Associated conditions – Celiac disease is frequently associated with dermatitis herpetiformis, selective IgA deficiency, and other conditions which have autoimmune features such as type 1 diabetes mellitus, thyroid disease, and other autoimmune diseases. (See 'Associated conditions' above.)

●Cancer risk – Patients with untreated celiac disease are at increased risk for lymphoma and gastrointestinal cancer. It remains unclear if early detection of celiac disease, the prior duration and severity of active celiac disease, or the degree of compliance with a gluten-free diet influence the rates of the associated cancers. (See 'Prognosis' above.)

  1. Kagnoff MF. Celiac disease. A gastrointestinal disease with environmental, genetic, and immunologic components. Gastroenterol Clin North Am 1992; 21:405.
  2. Schuppan D. Current concepts of celiac disease pathogenesis. Gastroenterology 2000; 119:234.
  3. Al-Toma A, Goerres MS, Meijer JW, et al. Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma. Clin Gastroenterol Hepatol 2006; 4:315.
  4. Pietzak MM, Schofield TC, McGinniss MJ, Nakamura RM. Stratifying risk for celiac disease in a large at-risk United States population by using HLA alleles. Clin Gastroenterol Hepatol 2009; 7:966.
  5. Liu E, Lee HS, Aronsson CA, et al. Risk of pediatric celiac disease according to HLA haplotype and country. N Engl J Med 2014; 371:42.
  6. Petronzelli F, Bonamico M, Ferrante P, et al. Genetic contribution of the HLA region to the familial clustering of coeliac disease. Ann Hum Genet 1997; 61:307.
  7. Houlston RS, Ford D. Genetics of coeliac disease. QJM 1996; 89:737.
  8. Houlston RS, Tomlinson IP, Ford D, et al. Linkage analysis of candidate regions for coeliac disease genes. Hum Mol Genet 1997; 6:1335.
  9. Greco L, Corazza G, Babron MC, et al. Genome search in celiac disease. Am J Hum Genet 1998; 62:669.
  10. Romanos J, van Diemen CC, Nolte IM, et al. Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease. Gastroenterology 2009; 137:834.
  11. Trynka G, Zhernakova A, Romanos J, et al. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Gut 2009; 58:1078.
  12. Kahaly GJ, Frommer L, Schuppan D. Celiac disease and endocrine autoimmunity - the genetic link. Autoimmun Rev 2018; 17:1169.
  13. Kahaly GJ, Frommer L, Schuppan D. Celiac Disease and Glandular Autoimmunity. Nutrients 2018; 10.
  14. Hunt KA, Zhernakova A, Turner G, et al. Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 2008; 40:395.
  15. Molberg O, Mcadam SN, Körner R, et al. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease. Nat Med 1998; 4:713.
  16. Schuppan D, Dieterich W, Riecken EO. Exposing gliadin as a tasty food for lymphocytes. Nat Med 1998; 4:666.
  17. van de Wal Y, Kooy Y, van Veelen P, et al. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity. J Immunol 1998; 161:1585.
  18. Shan L, Molberg Ø, Parrot I, et al. Structural basis for gluten intolerance in celiac sprue. Science 2002; 297:2275.
  19. Matysiak-Budnik T, Candalh C, Dugave C, et al. Alterations of the intestinal transport and processing of gliadin peptides in celiac disease. Gastroenterology 2003; 125:696.
  20. Matysiak-Budnik T, Moura IC, Arcos-Fajardo M, et al. Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease. J Exp Med 2008; 205:143.
  21. Lammers KM, Lu R, Brownley J, et al. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology 2008; 135:194.
  22. Halttunen T, Mäki M. Serum immunoglobulin A from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation. Gastroenterology 1999; 116:566.
  23. Esposito C, Paparo F, Caputo I, et al. Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ. Gut 2002; 51:177.
  24. Dieterich W, Trapp D, Esslinger B, et al. Autoantibodies of patients with coeliac disease are insufficient to block tissue transglutaminase activity. Gut 2003; 52:1562.
  25. Esposito C, Paparo F, Caputo I, et al. Expression and enzymatic activity of small intestinal tissue transglutaminase in celiac disease. Am J Gastroenterol 2003; 98:1813.
  26. Forsberg G, Hernell O, Melgar S, et al. Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease. Gastroenterology 2002; 123:667.
  27. Cellier C, Patey N, Mauvieux L, et al. Abnormal intestinal intraepithelial lymphocytes in refractory sprue. Gastroenterology 1998; 114:471.
  28. Brown I, Mino-Kenudson M, Deshpande V, Lauwers GY. Intraepithelial lymphocytosis in architecturally preserved proximal small intestinal mucosa: an increasing diagnostic problem with a wide differential diagnosis. Arch Pathol Lab Med 2006; 130:1020.
  29. Fritscher-Ravens A, Pflaum T, Mösinger M, et al. Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E. Gastroenterology 2019; 157:109.
  30. Maiuri L, Ciacci C, Ricciardelli I, et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 2003; 362:30.
  31. Schuppan D, Esslinger B, Dieterich W. Innate immunity and coeliac disease. Lancet 2003; 362:3.
  32. Jabri B, Kasarda DD, Green PH. Innate and adaptive immunity: the yin and yang of celiac disease. Immunol Rev 2005; 206:219.
  33. Londei M, Ciacci C, Ricciardelli I, et al. Gliadin as a stimulator of innate responses in celiac disease. Mol Immunol 2005; 42:913.
  34. Nikulina M, Habich C, Flohé SB, et al. Wheat gluten causes dendritic cell maturation and chemokine secretion. J Immunol 2004; 173:1925.
  35. Palová-Jelínková L, Rozková D, Pecharová B, et al. Gliadin fragments induce phenotypic and functional maturation of human dendritic cells. J Immunol 2005; 175:7038.
  36. Cinova J, Palová-Jelínková L, Smythies LE, et al. Gliadin peptides activate blood monocytes from patients with celiac disease. J Clin Immunol 2007; 27:201.
  37. Junker Y, Zeissig S, Kim SJ, et al. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med 2012; 209:2395.
  38. Carroccio A, Mansueto P, Soresi M, et al. Wheat Consumption Leads to Immune Activation and Symptom Worsening in Patients with Familial Mediterranean Fever: A Pilot Randomized Trial. Nutrients 2020; 12.
  39. Pickert G, Wirtz S, Matzner J, et al. Wheat Consumption Aggravates Colitis in Mice via Amylase Trypsin Inhibitor-mediated Dysbiosis. Gastroenterology 2020; 159:257.
  40. Bellinghausen I, Weigmann B, Zevallos V, et al. Wheat amylase-trypsin inhibitors exacerbate intestinal and airway allergic immune responses in humanized mice. J Allergy Clin Immunol 2019; 143:201.
  41. Zevallos VF, Raker V, Tenzer S, et al. Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells. Gastroenterology 2017; 152:1100.
  42. Catassi C, Alaedini A, Bojarski C, et al. The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update. Nutrients 2017; 9.
  43. Schuppan D, Gisbert-Schuppan K. Wheat syndromes: How wheat, gluten and ATI cause inflammation, IBS, and autoimmunity, Springer Nature, Basel 2019. p.1.
  44. Sher KS, Fraser RC, Wicks AC, Mayberry JF. High risk of coeliac disease in Punjabis. Epidemiological study in the south Asian and European populations of Leicestershire. Digestion 1993; 54:178.
  45. Rubio-Tapia A, Ludvigsson JF, Brantner TL, et al. The prevalence of celiac disease in the United States. Am J Gastroenterol 2012; 107:1538.
  46. Choung RS, Larson SA, Khaleghi S, et al. Prevalence and Morbidity of Undiagnosed Celiac Disease From a Community-Based Study. Gastroenterology 2017; 152:830.
  47. Gujral N, Freeman HJ, Thomson AB. Celiac disease: prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol 2012; 18:6036.
  48. Singh P, Arora A, Strand TA, et al. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 2018; 16:823.
  49. Cataldo F, Montalto G. Celiac disease in the developing countries: a new and challenging public health problem. World J Gastroenterol 2007; 13:2153.
  50. Catassi C, Fabiani E, Rätsch IM, et al. The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school-age subjects. Acta Paediatr Suppl 1996; 412:29.
  51. Pittschieler K, Ladinser B. Coeliac disease: screened by a new strategy. Acta Paediatr Suppl 1996; 412:42.
  52. Mäki M, Mustalahti K, Kokkonen J, et al. Prevalence of Celiac disease among children in Finland. N Engl J Med 2003; 348:2517.
  53. Grodzinsky E. Screening for coeliac disease in apparently healthy blood donors. Acta Paediatr Suppl 1996; 412:36.
  54. Tommasini A, Not T, Kiren V, et al. Mass screening for coeliac disease using antihuman transglutaminase antibody assay. Arch Dis Child 2004; 89:512.
  55. Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003; 163:286.
  56. Catassi C, Kryszak D, Louis-Jacques O, et al. Detection of Celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol 2007; 102:1454.
  57. Greco L, Percopo S. The coeliac disease task force " Free from Gluten," " Improved knowledge to cure coeliac disease". Acta Paediatr Suppl 1996; 412:25.
  58. Johnston SD, Watson RG, McMillan SA, et al. Preliminary results from follow-up of a large-scale population survey of antibodies to gliadin, reticulin and endomysium. Acta Paediatr Suppl 1996; 412:61.
  59. Kim HS, Patel KG, Orosz E, et al. Time Trends in the Prevalence of Celiac Disease and Gluten-Free Diet in the US Population: Results From the National Health and Nutrition Examination Surveys 2009-2014. JAMA Intern Med 2016; 176:1716.
  60. Gatti S, Lionetti E, Balanzoni L, et al. Increased Prevalence of Celiac Disease in School-age Children in Italy. Clin Gastroenterol Hepatol 2020; 18:596.
  61. Singh P, Arora S, Lal S, et al. Risk of Celiac Disease in the First- and Second-Degree Relatives of Patients With Celiac Disease: A Systematic Review and Meta-Analysis. Am J Gastroenterol 2015; 110:1539.
  62. RUBIN CE, BRANDBORG LL, PHELPS PC, TAYLOR HC Jr. Studies of celiac disease. I. The apparent identical and specific nature of the duodenal and proximal jejunal lesion in celiac disease and idiopathic sprue. Gastroenterology 1960; 38:28.
  63. Troncone R, Greco L, Mayer M, et al. Latent and potential coeliac disease. Acta Paediatr Suppl 1996; 412:10.
  64. Matysiak-Budnik T, Malamut G, de Serre NP, et al. Long-term follow-up of 61 coeliac patients diagnosed in childhood: evolution toward latency is possible on a normal diet. Gut 2007; 56:1379.
  65. Taavela J, Koskinen O, Huhtala H, et al. Validation of morphometric analyses of small-intestinal biopsy readouts in celiac disease. PLoS One 2013; 8:e76163.
  66. Gopal P, McKenna BJ. The collagenous gastroenteritides: similarities and differences. Arch Pathol Lab Med 2010; 134:1485.
  67. West J, Logan RF, Hill PG, Khaw KT. The iceberg of celiac disease: what is below the waterline? Clin Gastroenterol Hepatol 2007; 5:59.
  68. Taavela J, Kurppa K, Collin P, et al. Degree of damage to the small bowel and serum antibody titers correlate with clinical presentation of patients with celiac disease. Clin Gastroenterol Hepatol 2013; 11:166.
  69. Jamma S, Rubio-Tapia A, Kelly CP, et al. Celiac crisis is a rare but serious complication of celiac disease in adults. Clin Gastroenterol Hepatol 2010; 8:587.
  70. Zanini B, Caselani F, Magni A, et al. Celiac disease with mild enteropathy is not mild disease. Clin Gastroenterol Hepatol 2013; 11:253.
  71. Fry L, Seah PP, McMinn RM, Hoffbrand AV. Lymphocytic infiltration of epithelium in diagnosis of gluten-sensitive enteropathy. Br Med J 1972; 3:371.
  72. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue'). Gastroenterology 1992; 102:330.
  73. Marsh MN, Crowe PT. Morphology of the mucosal lesion in gluten sensitivity. Baillieres Clin Gastroenterol 1995; 9:273.
  74. Ferguson A, Arranz E, O'Mahony S. Clinical and pathological spectrum of coeliac disease--active, silent, latent, potential. Gut 1993; 34:150.
  75. Pastore L, Lo Muzio L, Serpico R. Atrophic glossitis leading to the diagnosis of celiac disease. N Engl J Med 2007; 356:2547.
  76. Lähteenoja H, Toivanen A, Viander M, et al. Oral mucosal changes in coeliac patients on a gluten-free diet. Eur J Oral Sci 1998; 106:899.
  77. Kemppainen T, Kröger H, Janatuinen E, et al. Osteoporosis in adult patients with celiac disease. Bone 1999; 24:249.
  78. Shaker JL, Brickner RC, Findling JW, et al. Hypocalcemia and skeletal disease as presenting features of celiac disease. Arch Intern Med 1997; 157:1013.
  79. Mustalahti K, Collin P, Sievänen H, et al. Osteopenia in patients with clinically silent coeliac disease warrants screening. Lancet 1999; 354:744.
  80. Bottaro G, Cataldo F, Rotolo N, et al. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases. Am J Gastroenterol 1999; 94:691.
  81. Selby PL, Davies M, Adams JE, Mawer EB. Bone loss in celiac disease is related to secondary hyperparathyroidism. J Bone Miner Res 1999; 14:652.
  82. Fickling WE, McFarlane XA, Bhalla AK, Robertson DA. The clinical impact of metabolic bone disease in coeliac disease. Postgrad Med J 2001; 77:33.
  83. Mora S, Weber G, Barera G, et al. Effect of gluten-free diet on bone mineral content in growing patients with celiac disease. Am J Clin Nutr 1993; 57:224.
  84. West J, Logan RF, Card TR, et al. Fracture risk in people with celiac disease: a population-based cohort study. Gastroenterology 2003; 125:429.
  85. Lubrano E, Ciacci C, Ames PR, et al. The arthritis of coeliac disease: prevalence and pattern in 200 adult patients. Br J Rheumatol 1996; 35:1314.
  86. Carroccio A, Iannitto E, Cavataio F, et al. Sideropenic anemia and celiac disease: one study, two points of view. Dig Dis Sci 1998; 43:673.
  87. Fine KD. The prevalence of occult gastrointestinal bleeding in celiac sprue. N Engl J Med 1996; 334:1163.
  88. Murray JA, McLachlan S, Adams PC, et al. Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians. Clin Gastroenterol Hepatol 2013; 11:808.
  89. Ackerman Z, Eliakim R, Stalnikowicz R, Rachmilewitz D. Role of small bowel biopsy in the endoscopic evaluation of adults with iron deficiency anemia. Am J Gastroenterol 1996; 91:2099.
  90. Carroccio A, Giannitrapani L, Di Prima L, et al. Extreme thrombocytosis as a sign of coeliac disease in the elderly: case report. Eur J Gastroenterol Hepatol 2002; 14:897.
  91. Schmitz F, Herzig KH, Stüber E, et al. On the pathogenesis and clinical course of mesenteric lymph node cavitation and hyposplenism in coeliac disease. Int J Colorectal Dis 2002; 17:192.
  92. Johnston SD, Robinson J. Fatal pneumococcal septicaemia in a coeliac patient. Eur J Gastroenterol Hepatol 1998; 10:353.
  93. McKinley M, Leibowitz S, Bronzo R, et al. Appropriate response to pneumococcal vaccine in celiac sprue. J Clin Gastroenterol 1995; 20:113.
  94. Cicarelli G, Della Rocca G, Amboni M, et al. Clinical and neurological abnormalities in adult celiac disease. Neurol Sci 2003; 24:311.
  95. Chin RL, Sander HW, Brannagan TH, et al. Celiac neuropathy. Neurology 2003; 60:1581.
  96. Addolorato G, Stefanini GF, Capristo E, et al. Anxiety and depression in adult untreated celiac subjects and in patients affected by inflammatory bowel disease: a personality "trait" or a reactive illness? Hepatogastroenterology 1996; 43:1513.
  97. Hadjivassiliou M, Chattopadhyay AK, Davies-Jones GA, et al. Neuromuscular disorder as a presenting feature of coeliac disease. J Neurol Neurosurg Psychiatry 1997; 63:770.
  98. Cronin CC, Jackson LM, Feighery C, et al. Coeliac disease and epilepsy. QJM 1998; 91:303.
  99. Hu WT, Murray JA, Greenaway MC, et al. Cognitive impairment and celiac disease. Arch Neurol 2006; 63:1440.
  100. Hadjivassiliou M, Gibson A, Davies-Jones GA, et al. Does cryptic gluten sensitivity play a part in neurological illness? Lancet 1996; 347:369.
  101. Hadjivassiliou M, Grünewald RA, Chattopadhyay AK, et al. Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia. Lancet 1998; 352:1582.
  102. Hadjivassiliou M, Grünewald RA, Lawden M, et al. Headache and CNS white matter abnormalities associated with gluten sensitivity. Neurology 2001; 56:385.
  103. Addolorato G, Di Giuda D, De Rossi G, et al. Regional cerebral hypoperfusion in patients with celiac disease. Am J Med 2004; 116:312.
  104. Hadjivassiliou M, Mäki M, Sanders DS, et al. Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia. Neurology 2006; 66:373.
  105. Banerji NK, Hurwitz LJ. Neurological manifestations in adult steatorrhoea (probable Gluten enteropathy). J Neurol Sci 1971; 14:125.
  106. Kaplan JG, Pack D, Horoupian D, et al. Distal axonopathy associated with chronic gluten enteropathy: a treatable disorder. Neurology 1988; 38:642.
  107. Usai P, Usai Satta P, Lai M, et al. Autonomic dysfunction and upper digestive functional disorders in untreated adult coeliac disease. Eur J Clin Invest 1997; 27:1009.
  108. Ludvigsson JF, Zingone F, Tomson T, et al. Increased risk of epilepsy in biopsy-verified celiac disease: a population-based cohort study. Neurology 2012; 78:1401.
  109. Dimitrova AK, Ungaro RC, Lebwohl B, et al. Prevalence of migraine in patients with celiac disease and inflammatory bowel disease. Headache 2013; 53:344.
  110. Ludvigsson JF, Reutfors J, Osby U, et al. Coeliac disease and risk of mood disorders--a general population-based cohort study. J Affect Disord 2007; 99:117.
  111. Garud S, Leffler D, Dennis M, et al. Interaction between psychiatric and autoimmune disorders in coeliac disease patients in the Northeastern United States. Aliment Pharmacol Ther 2009; 29:898.
  112. Ludvigsson JF, Olsson T, Ekbom A, Montgomery SM. A population-based study of coeliac disease, neurodegenerative and neuroinflammatory diseases. Aliment Pharmacol Ther 2007; 25:1317.
  113. Luostarinen L, Himanen SL, Luostarinen M, et al. Neuromuscular and sensory disturbances in patients with well treated coeliac disease. J Neurol Neurosurg Psychiatry 2003; 74:490.
  114. Meini A, Pillan NM, Villanacci V, et al. Prevalence and diagnosis of celiac disease in IgA-deficient children. Ann Allergy Asthma Immunol 1996; 77:333.
  115. Cataldo F, Marino V, Bottaro G, et al. Celiac disease and selective immunoglobulin A deficiency. J Pediatr 1997; 131:306.
  116. Schuppan D, Hahn EG. Celiac disease and its link to type 1 diabetes mellitus. J Pediatr Endocrinol Metab 2001; 14 Suppl 1:597.
  117. Acerini CL, Ahmed ML, Ross KM, et al. Coeliac disease in children and adolescents with IDDM: clinical characteristics and response to gluten-free diet. Diabet Med 1998; 15:38.
  118. Cronin CC, Feighery A, Ferriss JB, et al. High prevalence of celiac disease among patients with insulin-dependent (type I) diabetes mellitus. Am J Gastroenterol 1997; 92:2210.
  119. Talal AH, Murray JA, Goeken JA, Sivitz WI. Celiac disease in an adult population with insulin-dependent diabetes mellitus: use of endomysial antibody testing. Am J Gastroenterol 1997; 92:1280.
  120. Seissler J, Schott M, Boms S, et al. Autoantibodies to human tissue transgutaminase identify silent coeliac disease in Type I diabetes. Diabetologia 1999; 42:1440.
  121. Kordonouri O, Dieterich W, Schuppan D, et al. Autoantibodies to tissue transglutaminase are sensitive serological parameters for detecting silent coeliac disease in patients with Type 1 diabetes mellitus. Diabet Med 2000; 17:441.
  122. Hummel M, Bonifacio E, Stern M, et al. Development of celiac disease-associated antibodies in offspring of parents with type I diabetes. Diabetologia 2000; 43:1005.
  123. Corrao G, Corazza GR, Bagnardi V, et al. Mortality in patients with coeliac disease and their relatives: a cohort study. Lancet 2001; 358:356.
  124. Smyth DJ, Plagnol V, Walker NM, et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med 2008; 359:2767.
  125. Bao F, Yu L, Babu S, et al. One third of HLA DQ2 homozygous patients with type 1 diabetes express celiac disease-associated transglutaminase autoantibodies. J Autoimmun 1999; 13:143.
  126. Galli-Tsinopoulou A, Nousia-Arvanitakis S, Dracoulacos D, et al. Autoantibodies predicting diabetes mellitus type I in celiac disease. Horm Res 1999; 52:119.
  127. Saukkonen T, Savilahti E, Reijonen H, et al. Coeliac disease: frequent occurrence after clinical onset of insulin-dependent diabetes mellitus. Childhood Diabetes in Finland Study Group. Diabet Med 1996; 13:464.
  128. Westman E, Ambler GR, Royle M, et al. Children with coeliac disease and insulin dependent diabetes mellitus--growth, diabetes control and dietary intake. J Pediatr Endocrinol Metab 1999; 12:433.
  129. Meddings JB, Jarand J, Urbanski SJ, et al. Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat. Am J Physiol 1999; 276:G951.
  130. Funda DP, Kaas A, Bock T, et al. Gluten-free diet prevents diabetes in NOD mice. Diabetes Metab Res Rev 1999; 15:323.
  131. Ziegler AG, Schmid S, Huber D, et al. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 2003; 290:1721.
  132. Counsell CE, Taha A, Ruddell WS. Coeliac disease and autoimmune thyroid disease. Gut 1994; 35:844.
  133. Badenhoop K, Dieterich W, Segni M, et al. HLA DQ2 and/or DQ8 is associated with celiac disease-specific autoantibodies to tissue transglutaminase in families with thyroid autoimmunity. Am J Gastroenterol 2001; 96:1648.
  134. Ciacci C, Cavallaro R, Iovino P, et al. Allergy prevalence in adult celiac disease. J Allergy Clin Immunol 2004; 113:1199.
  135. Nachman F, Vázquez H, González A, et al. Gastroesophageal reflux symptoms in patients with celiac disease and the effects of a gluten-free diet. Clin Gastroenterol Hepatol 2011; 9:214.
  136. Thompson JS, Lebwohl B, Reilly NR, et al. Increased incidence of eosinophilic esophagitis in children and adults with celiac disease. J Clin Gastroenterol 2012; 46:e6.
  137. Verzegnassi F, Bua J, De Angelis P, et al. Eosinophilic oesophagitis and coeliac disease: is it just a casual association? Gut 2007; 56:1029.
  138. Quaglietta L, Coccorullo P, Miele E, et al. Eosinophilic oesophagitis and coeliac disease: is there an association? Aliment Pharmacol Ther 2007; 26:487.
  139. Ooi CY, Day AS, Jackson R, et al. Eosinophilic esophagitis in children with celiac disease. J Gastroenterol Hepatol 2008; 23:1144.
  140. Leslie C, Mews C, Charles A, Ravikumara M. Celiac disease and eosinophilic esophagitis: a true association. J Pediatr Gastroenterol Nutr 2010; 50:397.
  141. Breen EG, Coghlan G, Connolly EC, et al. Increased association of ulcerative colitis and coeliac disease. Ir J Med Sci 1987; 156:120.
  142. Falchuk KR, Falchuk ZM. Selective immunoglobulin a deficiency, ulcerative colitis, and gluten-sensitive enteropathy--a unique association. Gastroenterology 1975; 69:503.
  143. Leeds JS, Höroldt BS, Sidhu R, et al. Is there an association between coeliac disease and inflammatory bowel diseases? A study of relative prevalence in comparison with population controls. Scand J Gastroenterol 2007; 42:1214.
  144. Einarsdottir E, Koskinen LL, Dukes E, et al. IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. BMC Med Genet 2009; 10:8.
  145. Glas J, Stallhofer J, Ripke S, et al. Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease. Am J Gastroenterol 2009; 104:1737.
  146. Shah A, Mayberry JF, Williams G, et al. Epidemiological survey of coeliac disease and inflammatory bowel disease in first-degree relatives of coeliac patients. Q J Med 1990; 74:283.
  147. Oxford EC, Nguyen DD, Sauk J, et al. Impact of coexistent celiac disease on phenotype and natural history of inflammatory bowel diseases. Am J Gastroenterol 2013; 108:1123.
  148. Green PH, Yang J, Cheng J, et al. An association between microscopic colitis and celiac disease. Clin Gastroenterol Hepatol 2009; 7:1210.
  149. Volta U, De Franceschi L, Lari F, et al. Coeliac disease hidden by cryptogenic hypertransaminasaemia. Lancet 1998; 352:26.
  150. Bardella MT, Vecchi M, Conte D, et al. Chronic unexplained hypertransaminasemia may be caused by occult celiac disease. Hepatology 1999; 29:654.
  151. Sainsbury A, Sanders DS, Ford AC. Meta-analysis: Coeliac disease and hypertransaminasaemia. Aliment Pharmacol Ther 2011; 34:33.
  152. Duggan JM, Duggan AE. Systematic review: the liver in coeliac disease. Aliment Pharmacol Ther 2005; 21:515.
  153. Kingham JG, Parker DR. The association between primary biliary cirrhosis and coeliac disease: a study of relative prevalences. Gut 1998; 42:120.
  154. Dickey W, McMillan SA, Callender ME. High prevalence of celiac sprue among patients with primary biliary cirrhosis. J Clin Gastroenterol 1997; 25:328.
  155. Abdo A, Meddings J, Swain M. Liver abnormalities in celiac disease. Clin Gastroenterol Hepatol 2004; 2:107.
  156. Ludvigsson JF, Elfström P, Broomé U, et al. Celiac disease and risk of liver disease: a general population-based study. Clin Gastroenterol Hepatol 2007; 5:63.
  157. Ludvigsson JF, Montgomery SM, Ekbom A. Risk of pancreatitis in 14,000 individuals with celiac disease. Clin Gastroenterol Hepatol 2007; 5:1347.
  158. Sadr-Azodi O, Sanders DS, Murray JA, Ludvigsson JF. Patients with celiac disease have an increased risk for pancreatitis. Clin Gastroenterol Hepatol 2012; 10:1136.
  159. Tata LJ, Card TR, Logan RF, et al. Fertility and pregnancy-related events in women with celiac disease: a population-based cohort study. Gastroenterology 2005; 128:849.
  160. Moleski SM, Lindenmeyer CC, Veloski JJ, et al. Increased rates of pregnancy complications in women with celiac disease. Ann Gastroenterol 2015; 28:236.
  161. Rujner J. [Age at menarche in girls with celiac disease]. Ginekol Pol 1999; 70:359.
  162. Ferguson R, Holmes GK, Cooke WT. Coeliac disease, fertility, and pregnancy. Scand J Gastroenterol 1982; 17:65.
  163. Gasbarrini A, Torre ES, Trivellini C, et al. Recurrent spontaneous abortion and intrauterine fetal growth retardation as symptoms of coeliac disease. Lancet 2000; 356:399.
  164. Kumar A, Meena M, Begum N, et al. Latent celiac disease in reproductive performance of women. Fertil Steril 2011; 95:922.
  165. Sher KS, Mayberry JF. Female fertility, obstetric and gynaecological history in coeliac disease: a case control study. Acta Paediatr Suppl 1996; 412:76.
  166. Meloni GF, Dessole S, Vargiu N, et al. The prevalence of coeliac disease in infertility. Hum Reprod 1999; 14:2759.
  167. Collin P, Vilska S, Heinonen PK, et al. Infertility and coeliac disease. Gut 1996; 39:382.
  168. Soni S, Badawy SZ. Celiac disease and its effect on human reproduction: a review. J Reprod Med 2010; 55:3.
  169. Kiefte-de Jong JC, Jaddoe VW, Uitterlinden AG, et al. Levels of antibodies against tissue transglutaminase during pregnancy are associated with reduced fetal weight and birth weight. Gastroenterology 2013; 144:726.
  170. Nørgård B, Fonager K, Sørensen HT, Olsen J. Birth outcomes of women with celiac disease: a nationwide historical cohort study. Am J Gastroenterol 1999; 94:2435.
  171. Sher KS, Jayanthi V, Probert CS, et al. Infertility, obstetric and gynaecological problems in coeliac sprue. Dig Dis 1994; 12:186.
  172. Farthing MJ, Rees LH, Edwards CR, Dawson AM. Male gonadal function in coeliac disease: 2. Sex hormones. Gut 1983; 24:127.
  173. Frustaci A, Cuoco L, Chimenti C, et al. Celiac disease associated with autoimmune myocarditis. Circulation 2002; 105:2611.
  174. Curione M, Barbato M, De Biase L, et al. Prevalence of coeliac disease in idiopathic dilated cardiomyopathy. Lancet 1999; 354:222.
  175. Ludvigsson JF, Montgomery SM, Ekbom A, et al. Small-intestinal histopathology and mortality risk in celiac disease. JAMA 2009; 302:1171.
  176. Ludvigsson JF, James S, Askling J, et al. Nationwide cohort study of risk of ischemic heart disease in patients with celiac disease. Circulation 2011; 123:483.
  177. Ludvigsson JF, de Faire U, Ekbom A, Montgomery SM. Vascular disease in a population-based cohort of individuals hospitalised with coeliac disease. Heart 2007; 93:1111.
  178. Peters U, Askling J, Gridley G, et al. Causes of death in patients with celiac disease in a population-based Swedish cohort. Arch Intern Med 2003; 163:1566.
  179. Wei L, Spiers E, Reynolds N, et al. The association between coeliac disease and cardiovascular disease. Aliment Pharmacol Ther 2008; 27:514.
  180. Green PH, Fleischauer AT, Bhagat G, et al. Risk of malignancy in patients with celiac disease. Am J Med 2003; 115:191.
  181. Booth CC. History of celiac disease. BMJ 1989; 298:527.
  182. Askling J, Linet M, Gridley G, et al. Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis. Gastroenterology 2002; 123:1428.
  183. Elfström P, Granath F, Ye W, Ludvigsson JF. Low risk of gastrointestinal cancer among patients with celiac disease, inflammation, or latent celiac disease. Clin Gastroenterol Hepatol 2012; 10:30.
  184. Elfström P, Granath F, Ekström Smedby K, et al. Risk of lymphoproliferative malignancy in relation to small intestinal histopathology among patients with celiac disease. J Natl Cancer Inst 2011; 103:436.
  185. Emilsson L, Semrad C, Lebwohl B, et al. Risk of Small Bowel Adenocarcinoma, Adenomas, and Carcinoids in a Nationwide Cohort of Individuals With Celiac Disease. Gastroenterology 2020; 159:1686.
  186. Rubio-Tapia A, Kyle RA, Kaplan EL, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology 2009; 137:88.
  187. Logan RF, Rifkind EA, Turner ID, Ferguson A. Mortality in celiac disease. Gastroenterology 1989; 97:265.
  188. Nielsen OH, Jacobsen O, Pedersen ER, et al. Non-tropical sprue. Malignant diseases and mortality rate. Scand J Gastroenterol 1985; 20:13.
  189. Catassi C, Fabiani E, Corrao G, et al. Risk of non-Hodgkin lymphoma in celiac disease. JAMA 2002; 287:1413.
  190. Anderson LA, McMillan SA, Watson RG, et al. Malignancy and mortality in a population-based cohort of patients with coeliac disease or "gluten sensitivity". World J Gastroenterol 2007; 13:146.
  191. Card TR, West J, Holmes GK. Risk of malignancy in diagnosed coeliac disease: a 24-year prospective, population-based, cohort study. Aliment Pharmacol Ther 2004; 20:769.
  192. Grainge MJ, West J, Solaymani-Dodaran M, et al. The long-term risk of malignancy following a diagnosis of coeliac disease or dermatitis herpetiformis: a cohort study. Aliment Pharmacol Ther 2012; 35:730.
Topic 4774 Version 35.0

References

1 : Celiac disease. A gastrointestinal disease with environmental, genetic, and immunologic components.

2 : Current concepts of celiac disease pathogenesis.

3 : Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma.

4 : Stratifying risk for celiac disease in a large at-risk United States population by using HLA alleles.

5 : Risk of pediatric celiac disease according to HLA haplotype and country.

6 : Genetic contribution of the HLA region to the familial clustering of coeliac disease.

7 : Genetics of coeliac disease.

8 : Linkage analysis of candidate regions for coeliac disease genes.

9 : Genome search in celiac disease.

10 : Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease.

11 : Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.

12 : Celiac disease and endocrine autoimmunity - the genetic link.

13 : Celiac Disease and Glandular Autoimmunity.

14 : Newly identified genetic risk variants for celiac disease related to the immune response.

15 : Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease.

16 : Exposing gliadin as a tasty food for lymphocytes.

17 : Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity.

18 : Structural basis for gluten intolerance in celiac sprue.

19 : Alterations of the intestinal transport and processing of gliadin peptides in celiac disease.

20 : Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease.

21 : Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3.

22 : Serum immunoglobulin A from patients with celiac disease inhibits human T84 intestinal crypt epithelial cell differentiation.

23 : Anti-tissue transglutaminase antibodies from coeliac patients inhibit transglutaminase activity both in vitro and in situ.

24 : Autoantibodies of patients with coeliac disease are insufficient to block tissue transglutaminase activity.

25 : Expression and enzymatic activity of small intestinal tissue transglutaminase in celiac disease.

26 : Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease.

27 : Abnormal intestinal intraepithelial lymphocytes in refractory sprue.

28 : Intraepithelial lymphocytosis in architecturally preserved proximal small intestinal mucosa: an increasing diagnostic problem with a wide differential diagnosis.

29 : Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E.

30 : Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease.

31 : Innate immunity and coeliac disease.

32 : Innate and adaptive immunity: the yin and yang of celiac disease.

33 : Gliadin as a stimulator of innate responses in celiac disease.

34 : Wheat gluten causes dendritic cell maturation and chemokine secretion.

35 : Gliadin fragments induce phenotypic and functional maturation of human dendritic cells.

36 : Gliadin peptides activate blood monocytes from patients with celiac disease.

37 : Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4.

38 : Wheat Consumption Leads to Immune Activation and Symptom Worsening in Patients with Familial Mediterranean Fever: A Pilot Randomized Trial.

39 : Wheat Consumption Aggravates Colitis in Mice via Amylase Trypsin Inhibitor-mediated Dysbiosis.

40 : Wheat amylase-trypsin inhibitors exacerbate intestinal and airway allergic immune responses in humanized mice.

41 : Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells.

42 : The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update.

43 : The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update.

44 : High risk of coeliac disease in Punjabis. Epidemiological study in the south Asian and European populations of Leicestershire.

45 : The prevalence of celiac disease in the United States.

46 : Prevalence and Morbidity of Undiagnosed Celiac Disease From a Community-Based Study.

47 : Celiac disease: prevalence, diagnosis, pathogenesis and treatment.

48 : Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis.

49 : Celiac disease in the developing countries: a new and challenging public health problem.

50 : The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school-age subjects.

51 : Coeliac disease: screened by a new strategy.

52 : Prevalence of Celiac disease among children in Finland.

53 : Screening for coeliac disease in apparently healthy blood donors.

54 : Mass screening for coeliac disease using antihuman transglutaminase antibody assay.

55 : Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study.

56 : Detection of Celiac disease in primary care: a multicenter case-finding study in North America.

57 : The coeliac disease task force " Free from Gluten," " Improved knowledge to cure coeliac disease".

58 : Preliminary results from follow-up of a large-scale population survey of antibodies to gliadin, reticulin and endomysium.

59 : Time Trends in the Prevalence of Celiac Disease and Gluten-Free Diet in the US Population: Results From the National Health and Nutrition Examination Surveys 2009-2014.

60 : Increased Prevalence of Celiac Disease in School-age Children in Italy.

61 : Risk of Celiac Disease in the First- and Second-Degree Relatives of Patients With Celiac Disease: A Systematic Review and Meta-Analysis.

62 : Studies of celiac disease. I. The apparent identical and specific nature of the duodenal and proximal jejunal lesion in celiac disease and idiopathic sprue.

63 : Latent and potential coeliac disease.

64 : Long-term follow-up of 61 coeliac patients diagnosed in childhood: evolution toward latency is possible on a normal diet.

65 : Validation of morphometric analyses of small-intestinal biopsy readouts in celiac disease.

66 : The collagenous gastroenteritides: similarities and differences.

67 : The iceberg of celiac disease: what is below the waterline?

68 : Degree of damage to the small bowel and serum antibody titers correlate with clinical presentation of patients with celiac disease.

69 : Celiac crisis is a rare but serious complication of celiac disease in adults.

70 : Celiac disease with mild enteropathy is not mild disease.

71 : Lymphocytic infiltration of epithelium in diagnosis of gluten-sensitive enteropathy.

72 : Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue').

73 : Morphology of the mucosal lesion in gluten sensitivity.

74 : Clinical and pathological spectrum of coeliac disease--active, silent, latent, potential.

75 : Atrophic glossitis leading to the diagnosis of celiac disease.

76 : Oral mucosal changes in coeliac patients on a gluten-free diet.

77 : Osteoporosis in adult patients with celiac disease.

78 : Hypocalcemia and skeletal disease as presenting features of celiac disease.

79 : Osteopenia in patients with clinically silent coeliac disease warrants screening.

80 : The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases.

81 : Bone loss in celiac disease is related to secondary hyperparathyroidism.

82 : The clinical impact of metabolic bone disease in coeliac disease.

83 : Effect of gluten-free diet on bone mineral content in growing patients with celiac disease.

84 : Fracture risk in people with celiac disease: a population-based cohort study.

85 : The arthritis of coeliac disease: prevalence and pattern in 200 adult patients.

86 : Sideropenic anemia and celiac disease: one study, two points of view.

87 : The prevalence of occult gastrointestinal bleeding in celiac sprue.

88 : Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians.

89 : Role of small bowel biopsy in the endoscopic evaluation of adults with iron deficiency anemia.

90 : Extreme thrombocytosis as a sign of coeliac disease in the elderly: case report.

91 : On the pathogenesis and clinical course of mesenteric lymph node cavitation and hyposplenism in coeliac disease.

92 : Fatal pneumococcal septicaemia in a coeliac patient.

93 : Appropriate response to pneumococcal vaccine in celiac sprue.

94 : Clinical and neurological abnormalities in adult celiac disease.

95 : Celiac neuropathy.

96 : Anxiety and depression in adult untreated celiac subjects and in patients affected by inflammatory bowel disease: a personality "trait" or a reactive illness?

97 : Neuromuscular disorder as a presenting feature of coeliac disease.

98 : Coeliac disease and epilepsy.

99 : Cognitive impairment and celiac disease.

100 : Does cryptic gluten sensitivity play a part in neurological illness?

101 : Clinical, radiological, neurophysiological, and neuropathological characteristics of gluten ataxia.

102 : Headache and CNS white matter abnormalities associated with gluten sensitivity.

103 : Regional cerebral hypoperfusion in patients with celiac disease.

104 : Autoantibody targeting of brain and intestinal transglutaminase in gluten ataxia.

105 : Neurological manifestations in adult steatorrhoea (probable Gluten enteropathy).

106 : Distal axonopathy associated with chronic gluten enteropathy: a treatable disorder.

107 : Autonomic dysfunction and upper digestive functional disorders in untreated adult coeliac disease.

108 : Increased risk of epilepsy in biopsy-verified celiac disease: a population-based cohort study.

109 : Prevalence of migraine in patients with celiac disease and inflammatory bowel disease.

110 : Coeliac disease and risk of mood disorders--a general population-based cohort study.

111 : Interaction between psychiatric and autoimmune disorders in coeliac disease patients in the Northeastern United States.

112 : A population-based study of coeliac disease, neurodegenerative and neuroinflammatory diseases.

113 : Neuromuscular and sensory disturbances in patients with well treated coeliac disease.

114 : Prevalence and diagnosis of celiac disease in IgA-deficient children.

115 : Celiac disease and selective immunoglobulin A deficiency.

116 : Celiac disease and its link to type 1 diabetes mellitus.

117 : Coeliac disease in children and adolescents with IDDM: clinical characteristics and response to gluten-free diet.

118 : High prevalence of celiac disease among patients with insulin-dependent (type I) diabetes mellitus.

119 : Celiac disease in an adult population with insulin-dependent diabetes mellitus: use of endomysial antibody testing.

120 : Autoantibodies to human tissue transgutaminase identify silent coeliac disease in Type I diabetes.

121 : Autoantibodies to tissue transglutaminase are sensitive serological parameters for detecting silent coeliac disease in patients with Type 1 diabetes mellitus.

122 : Development of celiac disease-associated antibodies in offspring of parents with type I diabetes.

123 : Mortality in patients with coeliac disease and their relatives: a cohort study.

124 : Shared and distinct genetic variants in type 1 diabetes and celiac disease.

125 : One third of HLA DQ2 homozygous patients with type 1 diabetes express celiac disease-associated transglutaminase autoantibodies.

126 : Autoantibodies predicting diabetes mellitus type I in celiac disease.

127 : Coeliac disease: frequent occurrence after clinical onset of insulin-dependent diabetes mellitus. Childhood Diabetes in Finland Study Group.

128 : Children with coeliac disease and insulin dependent diabetes mellitus--growth, diabetes control and dietary intake.

129 : Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat.

130 : Gluten-free diet prevents diabetes in NOD mice.

131 : Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies.

132 : Coeliac disease and autoimmune thyroid disease.

133 : HLA DQ2 and/or DQ8 is associated with celiac disease-specific autoantibodies to tissue transglutaminase in families with thyroid autoimmunity.

134 : Allergy prevalence in adult celiac disease.

135 : Gastroesophageal reflux symptoms in patients with celiac disease and the effects of a gluten-free diet.

136 : Increased incidence of eosinophilic esophagitis in children and adults with celiac disease.

137 : Eosinophilic oesophagitis and coeliac disease: is it just a casual association?

138 : Eosinophilic oesophagitis and coeliac disease: is there an association?

139 : Eosinophilic esophagitis in children with celiac disease.

140 : Celiac disease and eosinophilic esophagitis: a true association.

141 : Increased association of ulcerative colitis and coeliac disease.

142 : Selective immunoglobulin a deficiency, ulcerative colitis, and gluten-sensitive enteropathy--a unique association.

143 : Is there an association between coeliac disease and inflammatory bowel diseases? A study of relative prevalence in comparison with population controls.

144 : IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.

145 : Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease.

146 : Epidemiological survey of coeliac disease and inflammatory bowel disease in first-degree relatives of coeliac patients.

147 : Impact of coexistent celiac disease on phenotype and natural history of inflammatory bowel diseases.

148 : An association between microscopic colitis and celiac disease.

149 : Coeliac disease hidden by cryptogenic hypertransaminasaemia.

150 : Chronic unexplained hypertransaminasemia may be caused by occult celiac disease.

151 : Meta-analysis: Coeliac disease and hypertransaminasaemia.

152 : Systematic review: the liver in coeliac disease.

153 : The association between primary biliary cirrhosis and coeliac disease: a study of relative prevalences.

154 : High prevalence of celiac sprue among patients with primary biliary cirrhosis.

155 : Liver abnormalities in celiac disease.

156 : Celiac disease and risk of liver disease: a general population-based study.

157 : Risk of pancreatitis in 14,000 individuals with celiac disease.

158 : Patients with celiac disease have an increased risk for pancreatitis.

159 : Fertility and pregnancy-related events in women with celiac disease: a population-based cohort study.

160 : Increased rates of pregnancy complications in women with celiac disease.

161 : [Age at menarche in girls with celiac disease].

162 : Coeliac disease, fertility, and pregnancy.

163 : Recurrent spontaneous abortion and intrauterine fetal growth retardation as symptoms of coeliac disease.

164 : Latent celiac disease in reproductive performance of women.

165 : Female fertility, obstetric and gynaecological history in coeliac disease: a case control study.

166 : The prevalence of coeliac disease in infertility.

167 : Infertility and coeliac disease.

168 : Celiac disease and its effect on human reproduction: a review.

169 : Levels of antibodies against tissue transglutaminase during pregnancy are associated with reduced fetal weight and birth weight.

170 : Birth outcomes of women with celiac disease: a nationwide historical cohort study.

171 : Infertility, obstetric and gynaecological problems in coeliac sprue.

172 : Male gonadal function in coeliac disease: 2. Sex hormones.

173 : Celiac disease associated with autoimmune myocarditis.

174 : Prevalence of coeliac disease in idiopathic dilated cardiomyopathy.

175 : Small-intestinal histopathology and mortality risk in celiac disease.

176 : Nationwide cohort study of risk of ischemic heart disease in patients with celiac disease.

177 : Vascular disease in a population-based cohort of individuals hospitalised with coeliac disease.

178 : Causes of death in patients with celiac disease in a population-based Swedish cohort.

179 : The association between coeliac disease and cardiovascular disease.

180 : Risk of malignancy in patients with celiac disease.

181 : History of celiac disease

182 : Cancer incidence in a population-based cohort of individuals hospitalized with celiac disease or dermatitis herpetiformis.

183 : Low risk of gastrointestinal cancer among patients with celiac disease, inflammation, or latent celiac disease.

184 : Risk of lymphoproliferative malignancy in relation to small intestinal histopathology among patients with celiac disease.

185 : Risk of Small Bowel Adenocarcinoma, Adenomas, and Carcinoids in a Nationwide Cohort of Individuals With Celiac Disease.

186 : Increased prevalence and mortality in undiagnosed celiac disease.

187 : Mortality in celiac disease.

188 : Non-tropical sprue. Malignant diseases and mortality rate.

189 : Risk of non-Hodgkin lymphoma in celiac disease.

190 : Malignancy and mortality in a population-based cohort of patients with coeliac disease or "gluten sensitivity".

191 : Risk of malignancy in diagnosed coeliac disease: a 24-year prospective, population-based, cohort study.

192 : The long-term risk of malignancy following a diagnosis of coeliac disease or dermatitis herpetiformis: a cohort study.