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Supraspinal regions and their roles in pain processing

Supraspinal regions and their roles in pain processing
Summary of the main supraspinal regions and their roles in pain processing. Multiple cortical and subcortical structures are involved in various primary roles and aspects of the pain experience (as color-coded and labeled). Additional brain regions and networks not shown in the figure are involved in the pain experience.
SMA: supplementary motor area; M1: primary motor cortex; S1: primary somatosensory cortex; PFC: prefrontal cortex; ACC: anterior cingulate cortex; S2: secondary somatosensory cortex; TPJ: temporal-parietal junction; Ins: insular cortex; NAc: nucleus accumbens; Cd: caudate; Th: thalamus; Pu: putamen; Amg: amygdala; Hi: hippocampus; PAG: periacqueductal gray; LC: locus coeruleus; RVM: rostral ventral medulla.
From: Martucci KT, Mackey SC. Neuroimaging of Pain: Human Evidence and Clinical Relevance of Central Nervous System Processes and Modulation. Anesthesiology 2018; 128:1241. DOI: 10.1097/ALN.0000000000002137. Copyright © 2018 American Society of Anesthesiologists. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.
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