Summary of the main supraspinal regions and their roles in pain processing. Multiple cortical and subcortical structures are involved in various primary roles and aspects of the pain experience (as color-coded and labeled). Additional brain regions and networks not shown in the figure are involved in the pain experience.
From: Martucci KT, Mackey SC. Neuroimaging of Pain: Human Evidence and Clinical Relevance of Central Nervous System Processes and Modulation. Anesthesiology 2018; 128:1241. DOI:
10.1097/ALN.0000000000002137. Copyright © 2018 American Society of Anesthesiologists. Reproduced with permission from Wolters Kluwer Health. Unauthorized reproduction of this material is prohibited.
