Relationship of estimated endogenous circadian rhythm in relation to habitual sleep bout at location of origin (Eastern Standard Time [EST]) and desired sleep bout at destination (Greenwich Mean Time [GMT]). Melatonin and light avoidance/exposure is timed strategically at the destination to produce phase advance such that the endogenous circadian rhythm aligns with local time.
DLMO: dim light melatonin onset; CBTmin: core body temperature minimum.